Ficine

Base Information

Chemical Name:Ficine
CAS No.:2520-36-7
Molecular Formula:C₂₀H₁₉NO₄
Molecular Weight:337.375
Hs Code.:
ChEMBL ID:CHEMBL2029617
DSSTox Substance ID:DTXSID40948053
Metabolomics Workbench ID:23243
Nikkaji Number:J94.588I
Wikidata:Q5861543
Mol file:2520-36-7.mol

Synonyms:Ficine;2520-36-7;CHEBI:5059;5,7-dihydroxy-8-(1-methylpyrrolidin-2-yl)-2-phenylchromen-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-(1-methyl-2-pyrrolidinyl)-2-phenyl-, (-)-;(+/-)-Ficine;CHEMBL2029617;DTXSID40948053;LMPK12110158;Q5861543;5,7-Dihydroxy-8-(1-methylpyrrolidin-2-yl)-2-phenyl-4H-1-benzopyran-4-one

Suppliers and Price of Ficine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ficine

Chemical Property:

Vapor Pressure:2.45E-11mmHg at 25°C
Melting Point:235 °C
Boiling Point:517.7°C at 760 mmHg
PKA:5.89±0.40(Predicted)
Flash Point:266.9°C
PSA：73.91000
Density:1.345g/cm³
LogP:3.57580
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:337.13140809
Heavy Atom Count:25
Complexity:542

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCCC1C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4)O)O

Technology Process of Ficine

There total 4 articles about Ficine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 7225-08-3
2-hydroxy-1-methylpyrrolidine

: 480-40-0
5,7-dihydroxy-2-phenyl-chromen-4-one

: 2520-36-7,24191-68-2
ficine

: 2255-62-1,84277-23-6
5,7-dihydroxy-6-(1-methylpyrrolidin-2-yl)-2-phenyl-4H-chromen-4-one

Guidance literature:: In tetrahydrofuran; water; at 80 ℃; for 5h; Sealed tube;
DOI:10.1021/jm201727w

Reference yield:

: 2520-36-7,24191-68-2
ficine

: 2520-36-7
ficine

: 1363338-97-9
ficine

Guidance literature:: In isopropyl alcohol; Resolution of racemate;
DOI:10.1021/jm201727w

Reference yield:

: 7225-08-3
2-hydroxy-1-methylpyrrolidine

: 480-40-0
5,7-dihydroxy-2-phenyl-chromen-4-one

: 2520-36-7
ficine

: 1363338-97-9
ficine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; water / 5 h / 80 °C / Sealed tube

2: isopropyl alcohol / Resolution of racemate

In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm201727w