DL-Methionine sulfone

Base Information

• Chemical Name: DL-Methionine sulfone
• CAS No.: 820-10-0
• Deprecated CAS: 1118-85-0
• Molecular Formula: C5H11 N O4 S
• Molecular Weight: 181.213
• Hs Code.: 2922499990
• European Community (EC) Number: 212-466-4
• NSC Number: 62968
• UNII: 5503K54L0R
• DSSTox Substance ID: DTXSID50875588
• Nikkaji Number: J533.244C
• Wikidata: Q27261252
• Mol file: 820-10-0.mol

Synonyms:methionine sulfone;methionine sulfone, (+-)-isomer;methionine sulfone, (S)-isomer;methionine sulfone, 35S-labeled, (+-)-isomer

Chemical Property of DL-Methionine sulfone

Chemical Property:

• Vapor Pressure: 2.26E-09mmHg at 25°C
• Melting Point: ~250 °C (dec.)
• Boiling Point: 450.5oC at 760 mmHg
• PKA: 2.10±0.10(Predicted)
• Flash Point: 226.3oC
• PSA: 105.84000
• Density: 1.385g/cm3
• LogP: 0.61410
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Acid (Slightly), Water (Slightly, Heated)
• XLogP3: -3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 181.04087901
• Heavy Atom Count: 11
• Complexity: 227

Purity/Quality:

98%,99%, ^*data from raw suppliers

DL-Methionine Sulfone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CS(=O)(=O)CCC(C(=O)O)N

Technology Process of DL-Methionine sulfone

There total 7 articles about DL-Methionine sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

DL-methionine (59-51-8,26062-47-5,58576-49-1) → DL-methionine sulfone (820-10-0,1118-85-0)

Guidance literature:

With 2-hydroperoxyhexafluoro-2-propanol; In methanol; for 6.5h; Heating;

DOI:10.1016/S0040-4039(00)71446-8

Reference yield:

DL-methionine (59-51-8,26062-47-5,58576-49-1) → DL-methionine sulfone (820-10-0,1118-85-0) + methionine S-oxide (3226-65-1,86631-49-4,779988-65-7)

Guidance literature:

With 100H₂O*Ce₆Ge₃O₁₂₉W₃₀^(24-)*24Na⁽¹⁺⁾; dihydrogen peroxide; In water; at 20 ℃; for 0.583333h; Microwave irradiation;

DOI:10.1021/acs.inorgchem.9b01164

Reference yield:

methionine S-oxide (3226-65-1,86631-49-4,779988-65-7) → DL-methionine sulfone (820-10-0,1118-85-0)

Guidance literature:

With dihydrogen peroxide; In ammonium molybdate; water; acetonitrile; for 2h; Sonication;

DOI:10.1021/np900173d

upstream raw materials:

DL-methionine

acetylamino-(2-methanesulfonyl-ethyl)-malonic acid diethyl ester

dihydrogen peroxide

methionine S-oxide

Downstream raw materials:

N-(2,4-dinitro-phenyl)-methionine S,S-dioxide

bromodichloromethane

chloroform

chlorodibromomethane

Refernces

• 1、 Dharma Rao,Baby Nirmala,Vani. "Kinetics and mechanism of iridium(III) catalysed oxidation of DL-methionine by alkaline hexacyanoferrate(III)". . p. 365 - 371. Retrieved 2013/05/22.
• 2、 Jimenez, Jorge I.,Vansach, Tifanie,Yoshida, Wesley Y.,Sakamoto, Bryan,Poerzgen, Peter,Horgen, F. David. "Halogenated fatty acid amides and cyclic depsipeptides from an eastern Caribbean collection of the cyanobacterium Lyngbya majuscula". supporting information; experimental part. p. 1573 - 1578. Retrieved 2010/03/31.