2-(1,3-Dioxolan-2-yl)-1-phenylethanone

Base Information

• Chemical Name: 2-(1,3-Dioxolan-2-yl)-1-phenylethanone
• CAS No.: 55337-55-8
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• NSC Number: 173198
• DSSTox Substance ID: DTXSID20306011
• Nikkaji Number: J1.290.144E
• Wikidata: Q82052876
• Mol file: 55337-55-8.mol

Synonyms:2-(1,3-dioxolan-2-yl)-1-phenylethanone;55337-55-8;2-(1,3-Dioxolan-2-yl)-1-phenyl-ethanone;NSC173198;DTXSID20306011;AKOS006371323;NSC-173198

Chemical Property of 2-(1,3-Dioxolan-2-yl)-1-phenylethanone

Chemical Property:

• Vapor Pressure: 0.000788mmHg at 25°C
• Boiling Point: 306.1°C at 760 mmHg
• Flash Point: 129.8°C
• Density: 1.145g/cm³
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)CC(=O)C2=CC=CC=C2

Technology Process of 2-(1,3-Dioxolan-2-yl)-1-phenylethanone

There total 17 articles about 2-(1,3-Dioxolan-2-yl)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1,3-DIOXOLANE (646-06-0) + styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane (55337-55-8)

Guidance literature:

With diatomite-supported manganese oxide nanoparticles; air; at 80 ℃; for 12h; regioselective reaction;

DOI:10.1021/jo2026367

Reference yield: 83.0%

2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane (100058-84-2) → 2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane (55337-55-8)

Guidance literature:

2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -78 ℃; for 0.583333h; Inert atmosphere; Schlenk technique;

With triethylamine; In dichloromethane; at -78 - 25 ℃; for 0.133333h; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0035-1561934

Reference yield: 70.0%

2-(3-oxo-3-phenylpropylidene)-1,3-dioxolane (128592-71-2) → 2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane (55337-55-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(01)80937-6

upstream raw materials:

3-Oxo-3-phenylpropanal

2-(3-oxo-3-phenylpropylidene)-1,3-dioxolane

2-((E)-Styryl)-[1,3]dioxolane

(E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one

Downstream raw materials:

2-(1,3-dithiolan-2-yl)-1-phenylethan-1-one

3-chloro-3-phenylpropiophenone

3-phenylisoxazole

5-phenylisoxazole