2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane

Base Information

• Chemical Name: 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane
• CAS No.: 100058-84-2
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol file: 100058-84-2.mol

Synonyms:2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane

Chemical Property of 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane

There total 9 articles about 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyleneglycol vinyl ether (764-48-7) + benzaldehyde (100-52-7) → 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane (100058-84-2)

Guidance literature:

ethyleneglycol vinyl ether; With isopropylmagnesium bromide; In diethyl ether; at 25 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere;

benzaldehyde; With scandium tris(trifluoromethanesulfonate); In diethyl ether; at 40 ℃; for 4h; Temperature; Solvent; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0035-1561934

Reference yield: 89.0%

2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane (55337-55-8) → 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane (100058-84-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80937-6

Reference yield: 25.0%

ethyleneglycol vinyl ether (764-48-7) + benzaldehyde (100-52-7) → 2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane (55337-55-8) + 2-(2'-hydroxy-2'-phenyl)ethyl-1,3-dioxolane (100058-84-2)

Guidance literature:

ethyleneglycol vinyl ether; With diisobutylaluminium hydride; In tetrahydrofuran; at 0 - 20 ℃;

benzaldehyde; In tetrahydrofuran; at 20 ℃; for 160h;

DOI:10.1055/s-2000-6480

upstream raw materials:

2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane

2-((E)-Styryl)-[1,3]dioxolane

2-[(E)-2-phenylethenyl]-1,3-dioxolane

ethyleneglycol vinyl ether

Downstream raw materials:

2-(2-oxo-2-phenyl-ethyl)-1,3-dioxolane

3-(benzyloxy)-3-phenylpropanal

Refernces

• 1、 Quinio, Pauline,Kohout, Laura,Roman, Daniela Sustac,Gaar, Jakob,Karaghiosoff, Konstantin,Knochel, Paul. "Sc(OTf)3-Catalyzed Addition of Bromomagnesium 2-Vinyloxy Ethoxide to Various Aldehydes Leading to Protected Aldol Products". . p. 1715 - 1719. Retrieved 2016.
• 2、 Matsushita, Yoh-ichi,Matsui, Takanao,Sugamoto, Kazuhiro. "Cobalt(II) Porphyrin-Catalyzed Oxidation of Olefins to Ketones with Molecular Oxygen and Triethylsilane in 2-Propanol". . p. 1381 - 1384. Retrieved 2007/10/02.