2,3-dihydro-2-(2-hydroxyethyl)-1H-Isoindol-1-one

Base Information

• Chemical Name: 2,3-dihydro-2-(2-hydroxyethyl)-1H-Isoindol-1-one
• CAS No.: 5334-06-5
• Molecular Formula: C10H11 N O2
• Molecular Weight: 177.1998
• Mol file: 5334-06-5.mol

Synonyms:Phthalimidine,2-(2-hydroxyethyl)- (6CI,8CI); 2-(2-Hydroxyethyl)-1-isoindolinone;N-(2-Hydroxyethyl)phthalimidine; NSC 2381

Chemical Property of 2,3-dihydro-2-(2-hydroxyethyl)-1H-Isoindol-1-one

Chemical Property:

• Vapor Pressure: 1.81E-06mmHg at 25°C
• Boiling Point: 380.5°Cat760mmHg
• Flash Point: 183.9°C
• PSA: 40.54000
• Density: 1.255g/cm³
• LogP: 0.57260

Purity/Quality:

2,3-dihydro-2-(2-hydroxyethyl)-1H-Isoindol-1-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydro-2-(2-hydroxyethyl)-1H-Isoindol-1-one

There total 13 articles about 2,3-dihydro-2-(2-hydroxyethyl)-1H-Isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(2-Hydroxyethyl)phthalimide (3891-07-4) → 2-(2-hydroxyethyl)-2,3-dihydro-1H-benzo[c]pyrrol-1-on (5334-06-5)

Guidance literature:

With ethanol; tetrabutylammonium tetrafluoroborate; diisopropylamine; at 20 ℃; for 3h; chemoselective reaction; Electrochemical reaction; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.1c00430

Reference yield: 88.0%

2-benzofuran-1(3H)-one (87-41-2) + ethanolamine (141-43-5) → 2-(2-hydroxyethyl)-2,3-dihydro-1H-benzo[c]pyrrol-1-on (5334-06-5)

Guidance literature:

at 150 - 210 ℃; for 21h;

DOI:10.1021/jm9502201

Reference yield: 71.0%

C10H10BrNO2 (1018331-22-0) → 2-(2-hydroxyethyl)-2,3-dihydro-1H-benzo[c]pyrrol-1-on (5334-06-5)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0028-1088048

upstream raw materials:

2-benzofuran-1(3H)-one

ethanolamine

N-(2-Hydroxyethyl)phthalimide

C₁₀H₁₀BrNO₂

Downstream raw materials:

2-(2-chloroethyl)-1-isoindolinone

C₁₀H₉NO₂

Toluene-4-sulfonic acid 2-(1-oxo-1,3-dihydro-isoindol-2-yl)-ethyl ester

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