2-(2-chloroethyl)isoindolin-1-one

Base Information

• Chemical Name: 2-(2-chloroethyl)isoindolin-1-one
• CAS No.: 41575-23-9
• Molecular Formula: C10H10ClNO
• Molecular Weight: 196
• Hs Code.: 2933790090
• Mol file: 41575-23-9.mol

Synonyms:2-(2-chloroethyl)isoindolin-1-one;1H-Isoindol-1-one, 2-(2-chloroethyl)-2,3-dihydro-

Chemical Property of 2-(2-chloroethyl)isoindolin-1-one

Chemical Property:

• Boiling Point: 349.2±42.0 °C(Predicted)
• PKA: -1.39±0.20(Predicted)
• PSA: 20.31000
• Density: 1.261±0.06 g/cm3(Predicted)
• LogP: 1.81910

Purity/Quality:

99%, ^*data from raw suppliers

2-(2-Chloroethyl)isoindolin-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-chloroethyl)isoindolin-1-one

There total 5 articles about 2-(2-chloroethyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(2-chlroethyl)phthalimide (6270-06-0) → 2-(2-chloroethyl)-1-isoindolinone (41575-23-9)

Guidance literature:

With ethanol; tetrabutylammonium tetrafluoroborate; diisopropylamine; at 20 ℃; for 2.5h; chemoselective reaction; Electrochemical reaction; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.1c00430

Reference yield: 91.0%

2-(2-hydroxyethyl)-2,3-dihydro-1H-benzo[c]pyrrol-1-on (5334-06-5) → 2-(2-chloroethyl)-1-isoindolinone (41575-23-9)

Guidance literature:

With thionyl chloride; In toluene; at 20 - 60 ℃; for 7h;

DOI:10.1021/jm9502201

Reference yield:

2-benzofuran-1(3H)-one (87-41-2) → 2-(2-chloroethyl)-1-isoindolinone (41575-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 21 h / 150 - 210 °C

2: 91 percent / SOCl₂ / toluene / 7 h / 20 - 60 °C

With thionyl chloride; In toluene;

DOI:10.1021/jm9502201

upstream raw materials:

2-(2-hydroxyethyl)-2,3-dihydro-1H-benzo[c]pyrrol-1-on

2-benzofuran-1(3H)-one

N-(2-chlroethyl)phthalimide

N-(2-Hydroxyethyl)phthalimide

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