N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE

Base Information

• Chemical Name: N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE
• CAS No.: 83440-03-3
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.217
• Hs Code.: 2933399090
• Mol file: 83440-03-3.mol

Synonyms:SG 209;

Chemical Property of N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE

Chemical Property:

• Vapor Pressure: 1.27E-07mmHg at 25°C
• Boiling Point: 430.7°C at 760 mmHg
• Flash Point: 214.3°C
• PSA: 68.29000
• Density: 1.182g/cm³
• LogP: 0.76540
• Storage Temp.: −20°C
• Solubility.: DMSO: ~24 mg/mL, soluble

Purity/Quality:

99% ^*data from raw suppliers

SG-209 air sensitive ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Nicotinamidoethyl acetate is an pinacidil analogue nicorandil which is potassium channel opener and nitric oxide donor which inhibits release of TNFα from lymphocyte cell line and peripheral blood lymphocyte.

Technology Process of N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE

There total 2 articles about N-[2-(ACETOXY)ETHYL]-3-PYRIDINECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-hydroxyethyl)nicotinamide (6265-73-2) + acetyl chloride (75-36-5) → N-[2-(acetoxy)ethyl]-3-pyridinecarboxamide (83440-03-3)

Guidance literature:

Product distribution / selectivity;

Reference yield:

→ N-[2-(acetoxy)ethyl]-3-pyridinecarboxamide (83440-03-3)

Guidance literature:

upstream raw materials:

N-(2-hydroxyethyl)nicotinamide

acetyl chloride

Refernces

• 1、 -. "Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof". . . Retrieved 2008/06/13.