6265-73-2

Basic information

• Product Name: N-(2-HYDROXYETHYL)NITOTINAMIDE
• Synonyms: N-(2-HYDROXYETHYL)NITOTINAMIDE;N-(2-hydroxyethyl)nicotinamide;N-(2-Hydroxyethyl)-3-Pyridine Carboxamide;SG-86;Nicorandil Impurity 1
• CAS NO: 6265-73-2
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.179
• Mol File: 6265-73-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 442.8 °C at 760 mmHg
• Flash Point: 221.6 °C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 1.28E-08mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 12.94±0.46(Predicted)
• CAS DataBase Reference: N-(2-HYDROXYETHYL)NITOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-HYDROXYETHYL)NITOTINAMIDE(6265-73-2)
• EPA Substance Registry System: N-(2-HYDROXYETHYL)NITOTINAMIDE(6265-73-2)

Safety Data

• Hazardous Substances Data: 6265-73-2(Hazardous Substances Data)

Usage

Uses

N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal.

InChI:InChI=1/C8H10N2O2/c11-5-4-10-8(12)7-2-1-3-9-6-7/h1-3,6,11H,4-5H2,(H,10,12)

Upstream product

• 88598-33-8 2-aminoethyl nicotinate nitrate 

Downstream Products

• 88354-02-3 2-Acetoxy-benzoic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester 
• 88353-97-3 2-<2-<(3-pyridinylcarbonyl)amino>ethyloxy>-2-methyl-4H-1,3-benzodioxin-4-one 
• 122048-13-9 2-<(3-pyridinylcarbonyl)amino>ethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 761415-94-5 2-(5-benzoyl-thiophen-2-yl)-propionic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester 
• 761415-91-2 2-(4-isobutyl-phenyl)-propionic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester 
• 761415-93-4 2-(4-benzoyl-phenyl)-propionic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester 
• 761415-92-3 [1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester 
• 83440-03-3 N-[2-(acetoxy)ethyl]-3-pyridinecarboxamide 
• 65141-46-0 N-(2-nitroxyethyl)nicotinamide 
• 121125-51-7 2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>ethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 121125-47-1 <2S-(2α,5α,6β)>-3-<<<2-<<<3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>hept-2-yl>carbonyl>oxy>ethyl>amino>carbonyl>-1-methylpyridinium iodide 
• 167409-41-8 2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 129904-66-1 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester 
• 92565-05-4 2-(nicotinoylamino)ethyl 2-(3-nitrobenzylidene)acetoacetate 

Relevant articles and documents

The stability of nicorandil in aqueous solution. I. Kinetics and mechanism of decomposition of N-(2-hydroxyethyl)nicotinamide nitrate (ester) in aqueous solution

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