[(1R,2S)-2-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl]acetaldehyde

Base Information

Chemical Name:[(1R,2S)-2-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl]acetaldehyde
CAS No.:101859-27-2
Molecular Formula:C14H28 O2 Si
Molecular Weight:256.4564
Hs Code.:

Synonyms:Cyclohexaneacetaldehyde,2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, trans-; 2-[trans-2-[(tert-Butyldimethylsilanyl)oxy]cyclohexyl]acetaldehyde

Suppliers and Price of [(1R,2S)-2-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl]acetaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of [(1R,2S)-2-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl]acetaldehyde

Chemical Property:

Vapor Pressure:0.00159mmHg at 25°C
Boiling Point:294.8°C at 760 mmHg
Flash Point:109.8°C
Density:0.91g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [(1R,2S)-2-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl]acetaldehyde

There total 4 articles about [(1R,2S)-2-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl]acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 101859-26-1
(1R*,2S*)-((2-tert-butyldimethylsilyl)-oxy)cyclohexaneacetonitryle

: 101859-27-2
(2-t-butyldimethylsiloxy)cyclohexylacetaldehyde

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 - 0 ℃;
DOI:10.1021/jo00362a014

Reference yield:

: 201230-82-2
carbon monoxide

: 72726-56-8
tert-butyl(dimethyl)[(2-methylenecyclohexyl)oxy]silane

: 101859-27-2
(2-t-butyldimethylsiloxy)cyclohexylacetaldehyde

: [(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-acetaldehyde

Guidance literature:: With hydrogen; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In benzene; at 20 ℃; under 51716.2 Torr; Title compound not separated from byproducts.;
DOI:10.1021/jo001751m

Reference yield:

: 74708-24-0,74708-25-1,90242-33-4,101976-91-4,74629-88-2
(1R*,2S*)-2-hydroxycyclohexane acetonitrile

: 101859-27-2
(2-t-butyldimethylsiloxy)cyclohexylacetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / TEA, DMAP / tetrahydrofuran; dimethylformamide

2: 86 percent / dibal / toluene / -78 - 0 °C

With dmap; TEA; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00362a014