4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo-

Base Information

Chemical Name:4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo-
CAS No.:125055-50-7
Molecular Formula:C₁₁H₁₁N₃O₂
Molecular Weight:217.227
Hs Code.:
DSSTox Substance ID:DTXSID00154557
Wikidata:Q83021815

Synonyms:N,6-Dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidine-3-carboxamide;4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo-;125055-50-7;N,6-dimethyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide;SCHEMBL9128642;DTXSID00154557;YORPSDUDGJSDFZ-UHFFFAOYSA-N;LS-134049;6-methyl-4-oxo-N-methyl-4h-pyrido[1,2-a]pyrimidine-3-carboxamide

Suppliers and Price of 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo-

Chemical Property:

Density:1.31g/cm³
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:217.085126602
Heavy Atom Count:16
Complexity:484

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC2=NC=C(C(=O)N12)C(=O)NC

Technology Process of 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo-

There total 6 articles about 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, N,6-dimethyl-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₁₀H₇ClN₂O₂

: 74-89-5
methylamine

: 125055-50-7
6-methyl-4-oxo-N-methyl-4H-pyrido[1,2-a]pyrimidine-3-carboxamide

Guidance literature:: In tetrahydrofuran; at 20 ℃;
DOI:10.1007/s11224-022-01889-0

Reference yield:

: 32092-27-6
6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid

: 125055-50-7
6-methyl-4-oxo-N-methyl-4H-pyrido[1,2-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 0.17 h / -13 °C

2: CHCl₃ / 1 h / -13 °C

With triethylamine; In chloroform;

Reference yield:

: 1824-81-3
2-Amino-6-methylpyridine

: 125055-50-7
6-methyl-4-oxo-N-methyl-4H-pyrido[1,2-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 6 h / 100 °C

2: diphenylether / 4 h / 270 °C

3: hydrogenchloride; acetic acid; water / 3 h / Reflux

4: triethylamine; thionyl chloride / 20 °C

5: tetrahydrofuran / 20 °C

With hydrogenchloride; thionyl chloride; water; acetic acid; triethylamine; In tetrahydrofuran; diphenylether; toluene; 2: |Gould-Jacobs Reaction;
DOI:10.1007/s11224-022-01889-0