Ethyl 6-methoxyquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 6-methoxyquinoline-3-carboxylate
CAS No.:26660-48-0
Molecular Formula:C₁₃H₁₃NO₃
Molecular Weight:231.251
Hs Code.:2933499090
NSC Number:201246
DSSTox Substance ID:DTXSID90307994
Nikkaji Number:J2.699.477B
Wikidata:Q82055631
Mol file:26660-48-0.mol

Synonyms:ethyl 6-methoxyquinoline-3-carboxylate;26660-48-0;6-Methoxyquinoline-3-carboxylic acid ethyl ester;Ethyl6-methoxyquinoline-3-carboxylate;NSC201246;SCHEMBL545163;DTXSID90307994;NUBYMKNFTIBVKU-UHFFFAOYSA-N;3-ethoxycarbonyl-6-methoxyquinoline;6-methoxy-3-ethoxycarbonylquinoline;NSC-201246;SB69536;A877167

Suppliers and Price of Ethyl 6-methoxyquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl6-Methoxyquinoline-3-carboxylate
100mg
$ 350.00

Crysdot
Ethyl6-methoxyquinoline-3-carboxylate 95+%
1g
$ 556.00

Chemenu
Ethyl6-methoxyquinoline-3-carboxylate 95%
1g
$ 520.00

American Custom Chemicals Corporation
ETHYL-6-METHOXYQUINOLINE-3-CARBOXYLATE 95.00%
5MG
$ 500.29

Alichem
Ethyl6-methoxyquinoline-3-carboxylate
1g
$ 573.30

Total 14 raw suppliers

Chemical Property of Ethyl 6-methoxyquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:4.85E-05mmHg at 25°C
Melting Point:203-205 °C
Boiling Point:349°Cat760mmHg
PKA:3.25±0.14(Predicted)
Flash Point:164.9°C
PSA：48.42000
Density:1.184g/cm³
LogP:2.42010
Storage Temp.:2-8°C
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:231.08954328
Heavy Atom Count:17
Complexity:269

Purity/Quality:

97% ^*data from raw suppliers

Ethyl6-Methoxyquinoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C2C=CC(=CC2=C1)OC

Technology Process of Ethyl 6-methoxyquinoline-3-carboxylate

There total 8 articles about Ethyl 6-methoxyquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 22931-71-1
ethyl 4-chloro-6-methoxyquinolin-3-carboxylate

: 26660-48-0
ethyl 6-methoxyquinoline-3-carboxylate

Guidance literature:: With sodium tetrahydroborate; palladium dichloride; In methanol; at 20 ℃; for 1h;
DOI:10.1071/CH08505

Reference yield: 80.0%

: 6325-93-5
p-nitrobenzenesulfonamide

: C₁₅H₁₇BrO₅

: 26660-48-0
ethyl 6-methoxyquinoline-3-carboxylate

Guidance literature:: p-nitrobenzenesulfonamide; C₁₅H₁₇BrO₅; With 1,10-Phenanthroline; potassium carbonate; copper(l) chloride; In acetonitrile; at 80 ℃; for 12h; Schlenk technique; Sealed tube; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 80 ℃; for 3h; Schlenk technique; Sealed tube; Inert atmosphere;
DOI:10.1002/adsc.201201033

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 26660-48-0
ethyl 6-methoxyquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / dichloromethane / 1 h / 20 °C

2: sodium azide / dimethyl sulfoxide / 16.5 h / 0 - 20 °C

3: trifluorormethanesulfonic acid / toluene / 3 h / 20 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / ethyl acetate / 0.08 h

With sodium azide; trifluorormethanesulfonic acid; phosphorus tribromide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene;
DOI:10.1039/c3ob27493d