3-fluoro-6-methoxyquinoline

Base Information

• Chemical Name: 3-fluoro-6-methoxyquinoline
• CAS No.: 426842-85-5
• Molecular Formula: C10H8FNO
• Molecular Weight: 177.17500
• Hs Code.: 2933499090
• Mol file: 426842-85-5.mol

Synonyms:3-Fluoro-6-methoxy quinoline;Quinoline,3-fluoro-6-methoxy;

Chemical Property of 3-fluoro-6-methoxyquinoline

Chemical Property:

• Boiling Point: 284.0±20.0 °C(Predicted)
• PKA: 2.34±0.14(Predicted)
• PSA: 22.12000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 2.38250

Purity/Quality:

98.5% ^*data from raw suppliers

3-Fluoro-6-methoxyquinoline >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-6-methoxyquinoline

There total 24 articles about 3-fluoro-6-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloro-3-fluoro-6-methoxyquinoline → 4-chloro-3-fluoro-6-methoxyquinoline (426842-85-5)

Guidance literature:

With formic acid; 20% palladium hydroxide-activated charcoal; triethylamine; In Isopropyl acetate; at 20 - 25 ℃; for 17h; Inert atmosphere;

DOI:10.1021/acs.oprd.1c00414

Reference yield: 93.0%

2,4-dichloro-3-fluoro-6-methoxyquinoline (1086533-18-7) → 4-chloro-3-fluoro-6-methoxyquinoline (426842-85-5)

Guidance literature:

With palladium 10% on activated carbon; ammonia; hydrogen; In methanol; at 2 ℃; for 2h; under 7757.43 Torr; Reagent/catalyst;

DOI:10.1016/j.bmcl.2017.06.009

Reference yield: 76.0%

6-methoxy-3-quinolinediazonium fluoroborate → 4-chloro-3-fluoro-6-methoxyquinoline (426842-85-5)

Guidance literature:

6-methoxy-3-quinolinediazonium fluoroborate; In toluene; at 60 - 85 ℃; Heating / reflux;

With sodium hydroxide; In water; ethyl acetate; toluene; for 1.5h; pH=7 - 7.5;

upstream raw materials:

3-amino-6-methoxyquinoline

2,4-dichloro-3-fluoro-6-methoxyquinoline

4-methoxy-aniline

diisopropylamine

Downstream raw materials:

3-fluoroquinolin-6-ol

6-fluoro-quinoline-5-carbaldehyde

4-(2-(3-fluoro-6-methoxyquinolin-4-yl)-2-hydroxyethoxy)-1-(3-phenylcyclobutyl)piperidine-4-carboxylic acid

Refernces

• 1、 Mitton-Fry, Mark J.,Brickner, Steven J.,Hamel, Judith C.,Barham, Rose,Brennan, Lori,Casavant, Jeffrey M.,Ding, Xiaoyuan,Finegan, Steven,Hardink, Joel,Hoang, Thuy,Huband, Michael D.,Maloney, Meghan,Marfat, Anthony,McCurdy, Sandra P.,McLeod, Dale,Subramanyam, Chakrapani,Plotkin, Michael,Reilly, Usa,Schafer, John,Stone, Gregory G.,Uccello, Daniel P.,Wisialowski, Todd,Yoon, Kwansik,Zaniewski, Richard,Zook, Christopher. "Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV". . p. 3353 - 3358. Retrieved 2017.
• 2、 -. "Hepatitis C virus inhibitors". Page/Page column 599; 600. . Retrieved 2017/01/23.