3-AMINO-6-METHOXYQUINOLINE

Base Information

• Chemical Name: 3-AMINO-6-METHOXYQUINOLINE
• CAS No.: 29507-86-6
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.202
• Hs Code.: 2933499090
• Mol file: 29507-86-6.mol

Synonyms:Quinoline,3-amino-6-methoxy- (8CI);3-Amino-6-methoxyquinoline;6-Methoxy-3-aminoquinoline;

Chemical Property of 3-AMINO-6-METHOXYQUINOLINE

Chemical Property:

• Vapor Pressure: 8.45E-07mmHg at 25°C
• Refractive Index: 1.747
• Boiling Point: 350.7 °C at 760 mmHg
• PKA: 5.02±0.14(Predicted)
• Flash Point: 165.9 °C
• PSA: 48.14000
• Density: 1.217 g/cm³
• LogP: 2.40680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxyquinolin-3-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-6-METHOXYQUINOLINE

There total 15 articles about 3-AMINO-6-METHOXYQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-nitro-6-methoxyquinoline (159454-73-6) → 3-amino-6-methoxyquinoline (29507-86-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate;

Reference yield: 93.0%

6-methoxyquinoline-3-carboxamide (71083-30-2) → 3-amino-6-methoxyquinoline (29507-86-6)

Guidance literature:

6-methoxyquinoline-3-carboxamide; With sodium hypochlorite; sodium hydroxide; In water; acetonitrile; at 0 - 5 ℃; for 2.25h; Inert atmosphere;

In water; acetonitrile; at 35 - 40 ℃; Time; Inert atmosphere;

DOI:10.1021/acs.oprd.1c00414

Reference yield: 5.0%

→ 4-chloro-6-methoxy-3-aminoquinoline (169957-43-1) + 3-amino-6-methoxyquinoline (29507-86-6)

Guidance literature:

upstream raw materials:

3-nitro-6-methoxyquinoline

4-methoxy-aniline

(E)-3-(4-Methoxy-phenylamino)-2-nitro-propenal

p-anisidine hydrochloride

Downstream raw materials:

6-methoxy-3-quinolinol

4-chloro-3-fluoro-6-methoxyquinoline

3-aminoquinolin-6-ol

5-bromo-N-(6-hydroxyquinolin-3-yl)-2-methoxybenzenesulfonamide