HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE

Base Information

• Chemical Name: HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
• CAS No.: 19179-12-5
• Molecular Formula: C7H10 N2 O2
• Molecular Weight: 154.169
• Hs Code.: 2933990090
• Mol file: 19179-12-5.mol

Synonyms:1,4-Dioxoperhydropyrrolo[1,2-a]pyrazine;Cyclo(glycylprolyl); Glycine, cyclic dipeptide with proline; Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;Proline, cyclic dipeptide with glycine; Pyrrolopiperazine-2,5-dione

Chemical Property of HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 447.9°Cat760mmHg
• PKA: 13.21±0.20(Predicted)
• Flash Point: 224.7°C
• PSA: 49.41000
• Density: 1.32g/cm³
• LogP: -0.62610

Purity/Quality:

97% ^*data from raw suppliers

Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE

There total 30 articles about HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-carbobenzoxyglycylproline ethyl ester → Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (19179-12-5)

Guidance literature:

With hydrogen; 10% palladium on active carbon; In N,N-dimethyl-formamide; for 2h;

DOI:10.1007/BF02219346

Reference yield: 85.0%

N-Chloroacetyl-DL-proline ethyl ester (96163-75-6) → Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (19179-12-5)

Guidance literature:

With ammonia; In ethanol; for 48h; Ambient temperature;

DOI:10.1007/BF00768332

Reference yield: 63.0%

(R)-(+)-prolylglycine methyl ester trifluoroacetate (634922-10-4) → (R)-(+)-1,4-diazabicyclo<4.3.0>nonane-2,5-dione (3705-27-9,19179-12-5,62057-47-0,96193-26-9)

Guidance literature:

With triethylamine; In methanol; Heating;

DOI:10.1021/jm00068a007

upstream raw materials:

N-(1-glycyl-DL-prolyl)-glycin-ethyl ester

N-Chloroacetyl-DL-proline ethyl ester

N-prolylglycine

GlyOEt*HCl

Downstream raw materials:

glycine

octahydropyrrolo[1,2-a]pyrazine

L-proline

DL-10-<β-N-(1,4-Diazabicyclo<4.3.0>nonanyl)propionyl>-2-chlorophenothiazine

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