Losaxantrone

Base Information

• Chemical Name: Losaxantrone
• CAS No.: 88303-61-1
• Molecular Formula: C₂₂H₂₇N₅O₄*2ClH
• Molecular Weight: 498.409
• Mol file: 88303-61-1.mol

Synonyms:Anthra[1,9-cd]pyrazol-6(2H)-one,7-hydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-,dihydrochloride (9CI); CI 941; DUP 941; Losoxantrone hydrochloride; NSC 357885;PD 113785

Chemical Property of Losaxantrone

Chemical Property:

• Vapor Pressure: 5.59E-30mmHg at 25°C
• Boiling Point: 840.3°C at 760 mmHg
• Flash Point: 462°C
• PSA: 131.67000
• LogP: 2.07880

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Losaxantrone

There total 19 articles about Losaxantrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-hydroxy-2-{2-[(2-hydroxyethyl)amino]ethyl}-5-({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra(1,9-cd)pyrazol-6(2H)-one (88303-60-0) → losoxantrone (88303-61-1)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 0 ℃; for 2h;

DOI:10.1002/jhet.5570260117

Reference yield: 55.0%

5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-7-hydroxyanthra<1,9-cd>pyrazol-6(2H)-one hydrochloride (123839-75-8) + 2-(2-Aminoethylamino)ethanol (111-41-1) → losoxantrone (88303-61-1)

Guidance literature:

With pyridine;

DOI:10.1016/S0040-4039(00)73069-3

Reference yield:

2-<2-<(2-hydroxyethyl)amino>ethyl>-5-<<2-<(2-hydroxyethyl)amino>ethyl>amino>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one (88303-59-7) → losoxantrone (88303-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, / 20percent Pd(OH)2-C / acetic acid / Ambient temperature; atmospheric pressure

2: 88 percent / hydrogen chloride / propan-2-ol / 2 h / 0 °C

With hydrogenchloride; hydrogen; palladium hydroxide - carbon; In acetic acid; isopropyl alcohol;

DOI:10.1002/jhet.5570260117

upstream raw materials:

2-<2-<(2-hydroxyethyl)amino>ethyl>-5-<<2-<(2-hydroxyethyl)amino>ethyl>amino>-7-<(2,4,6-trimethylphenyl)methoxy>anthra<1,9-cd>pyrazol-6(2H)-one

7-hydroxy-2-{2-[(2-hydroxyethyl)amino]ethyl}-5-({2-[(2-hydroxyethyl)amino]ethyl}amino)anthra(1,9-cd)pyrazol-6(2H)-one

5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-7-hydroxyanthra<1,9-cd>pyrazol-6(2H)-one hydrochloride

2-(2-Aminoethylamino)ethanol