88303-60-0

Usage

InChI:InChI=1/C22H27N5O4/c28-12-9-23-6-7-25-15-4-5-16-20-19(15)22(31)18-14(2-1-3-17(18)30)21(20)26-27(16)11-8-24-10-13-29/h1-5,23-25,28-30H,6-13H2

Upstream product

• 88303-59-7 2-<2-<(2-hydroxyethyl)amino>ethyl>-5-<<2-<(2-hydroxyethyl)amino>ethyl>amino>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 123839-75-8 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-7-hydroxyanthra<1,9-cd>pyrazol-6(2H)-one hydrochloride 
• 111-41-1 2-(2-Aminoethylamino)ethanol 
• 6770-15-6 1,4-dichloro-5-hydroxy-9,10-anthracenedione 
• 123839-74-7 1,4-dichloro-5-<(2,4,6-trimethylphenyl)methoxy>-9,10-anthracenedione 
• 100-39-0 benzyl bromide 
• 88303-57-5 5-chloro-2-<2-<(2-hydroxyethyl)amino>ethyl>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 88303-56-4 1,4-dichloro-5-(phenylmethoxy)-9,10-anthracenedione 
• 109921-38-2 5-<<2-<(2-hydroxyethyl)amino>ethyl>amino>-2-<2-<(2-hydroxyethyl)(phenylmethyl)amino>ethyl>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 
• 109921-42-8 <5-chloro-2,6-dihydro-6-oxo-7-<(2,4,6-trimethylphenyl)methoxy>anthra<1,9-cd>pyrazol-2-yl>(2-hydroxyethyl)carbamic acid, 1,1-dimethylethyl ester 
• 109921-36-0 5-chloro-2-<2-<(2-hydroxyethyl)(phenylmethyl)amino>ethyl>-7-(phenylmethoxy)anthra<1,9-cd>pyrazol-6(2H)-one 

Downstream Products

• 88303-61-1 losoxantrone 

Relevant academic research and scientific papers

Intermediates for the synthesis of anthrapyrazolone anticancer agents

This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride

Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI-937, CI-941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of t

Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones

Substituted anthra[1,9-cd]pyrazol-6(2H-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed.