10.1016/j.ejmech.2010.03.012
This research aimed to explore novel urease inhibitors by synthesizing and characterizing three new mononuclear complexes of Cu(II) and Zn(II) with the Schiff base ligand 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol (HL). The purpose was to counteract the negative effects of urease activity, which is a nickel-containing enzyme that hydrolyzes urea to produce ammonia and carbamate, leading to increased ammonia concentrations and pH elevations with implications in medicine and agriculture. The study concluded that two Cu(II) complexes, [CuLNO3] (1) and [CuClL] (2), exhibited strong urease inhibitory activities with IC50 values lower than that of acetohydroxamic acid, a standard urease inhibitor, while the Zn(II) complex [Zn(CH3COO)L] (3) showed no activity at 100 mM concentration. The chemicals used in the process included 5-nitrosalicylaldehyde, N-(2-hydroxyethyl)ethylenediamine for the synthesis of HL, and metal salts such as copper nitrate, copper chloride, and zinc acetate for the formation of the respective complexes.
10.1021/jo00308a030
The study focuses on the synthesis of 1,4-dinitroanthracene-9,10-dione (2) and its subsequent transformations using various diamines. The researchers explored two methods for synthesizing 2, one involving trifluoroacetic anhydride and hydrogen peroxide, and the other using trifluoroacetic acid and hydrogen peroxide. They then investigated the displacement of the nitro groups in 2 by different diamines, such as N,N-dimethylethylenediamine, 2-[(2-aminoethyl)amino]ethanol, and ethylenediamine, to produce monosubstituted and bis-substituted anthracene-9,10-dione derivatives. The study also examined the sequential displacements of the nitro substituents by diamines to prepare unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones. The products were characterized using various analytical techniques, including melting point determination, proton NMR, and mass spectrometry.
T,
C
