Clobetasol

Base Information Edit

Chemical Name:Clobetasol
CAS No.:25122-41-2
Molecular Formula:C₂₂H₂₈ClFO₄
Molecular Weight:410.913
Hs Code.:
European Community (EC) Number:246-633-8
UNII:ADN79D536H
DSSTox Substance ID:DTXSID2048955
Nikkaji Number:J19.393C
Wikipedia:Clobetasol
NCI Thesaurus Code:C65339
RXCUI:2590
Metabolomics Workbench ID:43259
ChEMBL ID:CHEMBL1201362
Mol file:25122-41-2.mol

Synonyms:Clobetasol;Clobetasol 17 Propionate;Clobetasol 17-Propionate;Clobetasol Propionate;Clobex;Clofenazon;Cormax;Dermovate;Embeline;Embeline E;OLUX;Temovate

Suppliers and Price of Clobetasol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Clobetasol
100mg
$ 1210.00

Medical Isotopes, Inc.
Clobetasol
10 mg
$ 625.00

Medical Isotopes, Inc.
Clobetasol
100 mg
$ 2000.00

American Custom Chemicals Corporation
CLOBETASOL 95.00%
100MG
$ 1758.49

American Custom Chemicals Corporation
CLOBETASOL 95.00%
10MG
$ 697.34

Total 51 raw suppliers

Chemical Property of Clobetasol Edit

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Vapor Pressure:1.23E-14mmHg at 25°C
Melting Point:220-222°C
Refractive Index:1.582
Boiling Point:555.1 °C at 760 mmHg
PKA:12.03±0.70(Predicted)
Flash Point:289.5 °C
PSA：74.60000
Density:1.32 g/cm³
LogP:3.14220
Storage Temp.:-20?C Freezer
Solubility.:Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:410.1660152
Heavy Atom Count:28
Complexity:808

Purity/Quality:

99% ^*data from raw suppliers

Clobetasol ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 61-48/20/21-53-62
Safety Statements: 53-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)O)C)O)F)C
Isomeric SMILES:C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C
Recent ClinicalTrials:Impact of Topical Clobetasol on Gingival Crevicular Fluid miRNAs in Subjects Affected by Oral Lichen Planus
Recent EU Clinical Trials:A two-part (observational and intervention) study to explore disease characteristics of vulvar (pre)malignancies compared to healthy volunteers
Uses Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory. Topical corticosteroid. Glucocorticoid; anti-inflammatory.
Therapeutic Function Corticosteroid, Antiinflammatory

Technology Process of Clobetasol

There total 2 articles about Clobetasol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%