(E)-3-(Methylthio)propenoic acid 2-methoxybenzyl ester

Base Information

• Chemical Name: (E)-3-(Methylthio)propenoic acid 2-methoxybenzyl ester
• CAS No.: 107584-57-6
• Molecular Formula: C12H14 O3 S
• Molecular Weight: 238.30276
• Mol file: 107584-57-6.mol

Synonyms:2-Propenoicacid, 3-(methylthio)-, (2-methoxyphenyl)methyl ester, (E)-; Isotachin; IsotachinC

Chemical Property of (E)-3-(Methylthio)propenoic acid 2-methoxybenzyl ester

Chemical Property:

• PSA: 60.83000
• LogP: 2.61510

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-(Methylthio)propenoic acid 2-methoxybenzyl ester

There total 3 articles about (E)-3-(Methylthio)propenoic acid 2-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.5%

methylthiol (74-93-1) + 2-methoxy benzyl propynoate (131530-53-5) → (Z)-3-Methylsulfanyl-acrylic acid 2-methoxy-benzyl ester (131530-54-6) + isotachin 'C' (107584-57-6)

Guidance literature:

With triethylamine; In diethyl ether; at 0 ℃; for 24h; Yield given;

Reference yield:

(2-methoxyphenyl)methanol (612-16-8) → isotachin 'C' (107584-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / DCC, DMAP / diethyl ether / 10 h / Ambient temperature

2: 38.3 percent / Et₃N / diethyl ether / 24 h / 0 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In diethyl ether;

Reference yield:

dicyclohexyl-carbodiimide (538-75-0) → isotachin 'C' (107584-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / DMAP, 2-methoxybenzyl alcohol / diethyl ether / 10 h / Ambient temperature

2: 38.3 percent / Et₃N / diethyl ether / 24 h / 0 °C

With dmap; (2-methoxyphenyl)methanol; triethylamine; In diethyl ether;

upstream raw materials:

methylthiol

2-methoxy benzyl propynoate

(2-methoxyphenyl)methanol

dicyclohexyl-carbodiimide

Refernces