4-Isopropylmorpholine

Base Information

• Chemical Name: 4-Isopropylmorpholine
• CAS No.: 1004-14-4
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2934999090
• European Community (EC) Number: 642-980-8
• NSC Number: 148209
• DSSTox Substance ID: DTXSID7074951
• Nikkaji Number: J364.612B
• Wikidata: Q72486095
• Mol file: 1004-14-4.mol

Synonyms:4-isopropylmorpholine;1004-14-4;4-propan-2-ylmorpholine;Morpholine, isopropyl-;Morpholine, 4-(1-methylethyl)-;Isopropylmorpholine;Morpholine, (1-methylethyl)-;1331-24-4;4-(1-Methylethyl)morpholine;isopropyl morpholine;n-isopropylmorpholine;NIPM;4-iso-propylmorpholine;4-N-(Isopropyl)morpholine;4-(propan-2-yl)morpholine;C(C)(C)N1CCOCC1;SCHEMBL57306;DTXSID7074951;MFCD01713701;NSC148209;AKOS006242266;NSC 148209;NSC-148209;AS-40879;LS-93080;CS-0325541;FT-0735453;J-515603

Chemical Property of 4-Isopropylmorpholine

Chemical Property:

• Appearance/Colour: White or off-white crystal powder
• Vapor Pressure: 2.91mmHg at 25°C
• Refractive Index: 1.445
• Boiling Point: 156.3 °C at 760 mmHg
• Flash Point: 41.7 °C
• PSA: 12.47000
• Density: 0.918 g/cm³
• LogP: 0.66490
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 77

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Isopropylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)N1CCOCC1

Technology Process of 4-Isopropylmorpholine

There total 10 articles about 4-Isopropylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-chloro-1-(4-morpholino)propan-1-one (54022-76-3) → 4-isopropyl-morpholine (1004-14-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 20h; Heating;

DOI:10.1055/s-1983-30487

Reference yield: 20.0%

4-Isopropyl-4-methyl-morpholin-4-ium; iodide (93627-56-6) → 4-methyl-morpholine (109-02-4) + 4-isopropyl-morpholine (1004-14-4)

Guidance literature:

With sodium thiophenolate; In acetonitrile; butanone; Heating;

Reference yield:

morpholine (110-91-8,99108-56-2) + acetone (67-64-1) → 4-isopropyl-morpholine (1004-14-4)

Guidance literature:

With triethylamine-borane; In neat (no solvent); at 60 ℃; for 24h; under 760.051 Torr; Schlenk technique;

DOI:10.1039/d1cc02618f

upstream raw materials:

2-methyl-2-(morpholin-4-yl)propanenitrile

N,N-bis(2-hydroxyethyl)isopropylamine

morpholine

1-isopropyl-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt

Refernces

• 1、 Chen, Hangeng,Zhang, Tao,Qian, Chao,Chen, Xinzhi. "A novel method for N-alkylation of aliphatic amines with ethers over ?3-Al2O3". . p. 537 - 540. Retrieved 2015/03/05.
• 2、 Manoharan, T. Samuel,Madyastha, K. Madhava,Singh, B. B.,Bhatnagar, S. P.,Weiss, Ulrich. "Conveniant Method for Replacement of Tertiary N-Methyl by Other Alkyl Groups: Application to Morphine Alkaloids". . p. 5 - 11. Retrieved 2007/10/02.