(2-Bromoethyl)phosphonic dichloride

Base Information

• Chemical Name: (2-Bromoethyl)phosphonic dichloride
• CAS No.: 28482-01-1
• Molecular Formula: C2H4 Br Cl2 O P
• Molecular Weight: 225.837
• NSC Number: 138340
• DSSTox Substance ID: DTXSID10300684
• Wikidata: Q82043946
• Mol file: 28482-01-1.mol

Synonyms:(2-bromoethyl)phosphonic dichloride;28482-01-1;NSC138340;SCHEMBL699114;2-bromoethylphosphonic dichloride;DTXSID10300684;PJGSXAZUFMCQKA-UHFFFAOYSA-N;NSC-138340

Chemical Property of (2-Bromoethyl)phosphonic dichloride

Chemical Property:

• Vapor Pressure: 0.0297mmHg at 25°C
• Boiling Point: 253.1°C at 760 mmHg
• Flash Point: 106.9°C
• Density: 1.856g/cm³
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 223.85602
• Heavy Atom Count: 7
• Complexity: 89.7

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CBr)P(=O)(Cl)Cl

Technology Process of (2-Bromoethyl)phosphonic dichloride

There total 4 articles about (2-Bromoethyl)phosphonic dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

bis(trimethylsilyl) (2-bromoethyl)phosphonate (69310-54-9) → (2-bromoethyl)phosphonic dichloride (28482-01-1)

Guidance literature:

With oxalyl dichloride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)80597-9

Reference yield: 54.0%

ethylene dibromide (106-93-4) + diethyl trimethylsilyl phosphite (13716-45-5) → (2-bromoethyl)phosphonic dichloride (28482-01-1)

Guidance literature:

ethylene dibromide; diethyl trimethylsilyl phosphite; at 150 ℃; for 1h;

With phosphorus pentachloride; for 2h; Further stages.;

DOI:10.1134/S1070363206050094

Reference yield:

(2-bromo-ethyl)-phosphonic acid bis-(2-bromo-ethyl ester) (78-45-5) + phosphorus pentachloride (10026-13-8,874483-75-7) → (2-bromoethyl)phosphonic dichloride (28482-01-1) + 1-Bromo-2-chloroethane (107-04-0)

Guidance literature:

at 140 - 145 ℃;

upstream raw materials:

(2-bromo-ethyl)-phosphonic acid bis-(2-bromo-ethyl ester)

bis(trimethylsilyl) (2-bromoethyl)phosphonate

phosphorus pentachloride

ethylene dibromide

Downstream raw materials:

(2-bromoethyl)phosphonic acid

1-O-hexadecanoyl-3-O-<<2-(trimethylamino)ethyl>phosphoryl>propanediol

2-O-Benzyl-1-O-hexadecylglyceryl-3-(2-bromethyl-phosphonat)