2,2'-Sulfonylbis(1-phenylethanol)

Base Information

• Chemical Name: 2,2'-Sulfonylbis(1-phenylethanol)
• CAS No.: 2765-42-6
• Molecular Formula: C16H18 O4 S
• Molecular Weight: 306.3767
• NSC Number: 84519
• DSSTox Substance ID: DTXSID20292667
• Nikkaji Number: J2.256.275D
• Mol file: 2765-42-6.mol

Synonyms:2,2'-sulfonylbis(1-phenylethanol);2765-42-6;NSC84519;NCIOpen2_009527;DTXSID20292667;NSC-84519

Chemical Property of 2,2'-Sulfonylbis(1-phenylethanol)

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 306.09258022
• Heavy Atom Count: 21
• Complexity: 357

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CS(=O)(=O)CC(C2=CC=CC=C2)O)O

Technology Process of 2,2'-Sulfonylbis(1-phenylethanol)

There total 6 articles about 2,2'-Sulfonylbis(1-phenylethanol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-methanesulfonyl-1-phenyl-ethanol (5324-56-1) + benzaldehyde (100-52-7) → 2-(2-hydroxy-2-phenylethylsulfonyl)-1-phenyl-1-ethanol (2765-42-6)

Guidance literature:

2-methanesulfonyl-1-phenyl-ethanol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

DOI:10.1021/acs.joc.6b01827

Reference yield: 38.0%

bis(chloromethyl)sulfone (37557-97-4) + benzaldehyde (100-52-7) → 2-(2-hydroxy-2-phenylethylsulfonyl)-1-phenyl-1-ethanol (2765-42-6)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; at -90 ℃; for 2h;

DOI:10.1055/s-2005-918410

Reference yield:

Diphenacyl sulfone (3708-08-5) → 2-(2-hydroxy-2-phenylethylsulfonyl)-1-phenyl-1-ethanol (2765-42-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;

DOI:10.1002/cjoc.201400409

upstream raw materials:

dimethylsulfone

benzaldehyde

bis(chloromethyl)sulfone

Diphenacyl sulfone