Propionamide, N-(1,1-dimethyl-2-piperidinoethyl)-N-2-pyridyl-, (E)-

Base Information

• Chemical Name: Propionamide, N-(1,1-dimethyl-2-piperidinoethyl)-N-2-pyridyl-, (E)-
• CAS No.: 102129-05-5
• Molecular Formula: C₁₇H₂₇N₃O
• Molecular Weight: 289.421
• DSSTox Substance ID: DTXSID30144668
• Wikidata: Q83008916
• Mol file: 102129-05-5.mol

Synonyms:BRN 0424145;102129-05-5;Propionamide, N-(1,1-dimethyl-2-piperidinoethyl)-N-2-pyridyl-, (E)-;trans-N-(1,1-Dimethyl-2-piperidinoethyl)-N-2-pyridylpropionamide;5-22-08-00390 (Beilstein Handbook Reference);DTXSID30144668;LS-124195

Chemical Property of Propionamide, N-(1,1-dimethyl-2-piperidinoethyl)-N-2-pyridyl-, (E)-

Chemical Property:

• Vapor Pressure: 3.37E-07mmHg at 25°C
• Boiling Point: 418.1°C at 760 mmHg
• Flash Point: 206.6°C
• Density: 1.056g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 289.215412493
• Heavy Atom Count: 21
• Complexity: 337

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)N(C1=CC=CC=N1)C(C)(C)CN2CCCCC2

Technology Process of Propionamide, N-(1,1-dimethyl-2-piperidinoethyl)-N-2-pyridyl-, (E)-

There total 5 articles about Propionamide, N-(1,1-dimethyl-2-piperidinoethyl)-N-2-pyridyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-Dimethyl-1-nitro-2-piperidinoethan (17697-46-0) → N-(1,1-Dimethyl-2-piperidinoethyl)-N-(2-pyridyl)-propionamid (102129-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 258 g / hydrogen / Raney-nickel / ethanol / 30 - 50 °C / 36775.4 Torr

2: K₂CO₃, Cu powder / 48 h / 160 °C

3: CH₂Cl₂

With hydrogen; copper; potassium carbonate; nickel; In ethanol; dichloromethane;

Reference yield:

2-bromo-pyridine (109-04-6) → N-(1,1-Dimethyl-2-piperidinoethyl)-N-(2-pyridyl)-propionamid (102129-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, Cu powder / 48 h / 160 °C

2: CH₂Cl₂

With copper; potassium carbonate; In dichloromethane;

Reference yield:

2-methyl-1-(piperidin-1-yl)propan-2-amine (6105-74-4) → N-(1,1-Dimethyl-2-piperidinoethyl)-N-(2-pyridyl)-propionamid (102129-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, Cu powder / 48 h / 160 °C

2: CH₂Cl₂

With copper; potassium carbonate; In dichloromethane;

upstream raw materials:

propionyl chloride

2--pyridin

2-bromo-pyridine

2-methyl-1-(piperidin-1-yl)propan-2-amine

Refernces

• 1、 Hiltmann,Hoffmeister,Niemers,Schlichting,Wollweber. "2 Acylaminopyridine derivatives having agonistic and antagonistic activity to morphine". . p. 584 - 600. Retrieved 2007/10/04.