6105-74-4

Basic information

• Product Name: 1,1-DIMETHYL-2-PIPERIDIN-1-YL-ETHYLAMINE
• Synonyms: TIMTEC-BB SBB009727;AKOS B025043;1,1-DIMETHYL-2-PIPERIDIN-1-YL-ETHYLAMINE;2-METHYL-1-PIPERIDINO-2-PROPANAMINE;CHEMBRDG-BB 4014539;ART-CHEM-BB B025043;2-Methyl-1-piperidino-2-propaneamine;(1,1-dimethyl-2-piperidin-1-ylethyl)amine(SALTDATA: FREE)
• CAS NO: 6105-74-4
• Molecular Formula: C₉H₂₀N₂
• Molecular Weight: 156.27
• Mol File: 6105-74-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 67 °C
• Flash Point: 80.4 °C
• Appearance: /
• Density: 0.909 g/cm³
• Vapor Pressure: 0.153mmHg at 25°C
• Refractive Index: 1.478
• PKA: 10.25±0.25(Predicted)
• CAS DataBase Reference: 1,1-DIMETHYL-2-PIPERIDIN-1-YL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIMETHYL-2-PIPERIDIN-1-YL-ETHYLAMINE(6105-74-4)
• EPA Substance Registry System: 1,1-DIMETHYL-2-PIPERIDIN-1-YL-ETHYLAMINE(6105-74-4)

Safety Data

• Hazardous Substances Data: 6105-74-4(Hazardous Substances Data)

Usage

General Description

1,1-Dimethyl-2-piperidin-1-yl-ethylamine, also known as N,N-Dimethyl-1-(1-oxo-2-piperidinyl)ethylamine, is a chemical compound with the molecular formula C10H21N. It is a tertiary amine and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical is a pale yellow liquid with a characteristic odor and is soluble in water and organic solvents. It is known for its potential use as a reagent in organic chemistry reactions and as a building block in the synthesis of various drugs and compounds. However, it is important to handle this chemical with caution as it can be harmful if inhaled, ingested, or comes into contact with the skin or eyes.

InChI:InChI=1/C9H20N2/c1-9(2,10)8-11-6-4-3-5-7-11/h3-8,10H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 3010-03-5 piperidin-1-yl-acetonitrile 
• 75-16-1 methylmagnesium bromide 
• 17697-46-0 1,1-Dimethyl-1-nitro-2-piperidinoethan 

Downstream Products

• 102129-05-5 N-(1,1-Dimethyl-2-piperidinoethyl)-N-(2-pyridyl)-propionamid 
• 1174571-55-1 (E)-[2-(3-{4-[(1,1-Dimethyl-2-piperidin-1-yl-ethylamino)-(4-trifluoromethyl-phenylcarbamoyl)-methyl]-phenyl}-acryloylamino)-phenyl]-carbamic acid tert-butyl ester 
• 1265633-80-4 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-methyl-1-(piperidin-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide 

Relevant articles and documents

NOVEL C28-ANALOGUES WITH C3-MODIFICATIONS OF TRITERPENE DERIVATIVES AS HIV INHIBITORS

The present invention relates to compounds of novel C28-analogues with C3- modifications of triterpene derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, and Z are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.

Rapid Ti(Oi-Pr)4 facilitated synthesis of α,α,α-trisubstituted primary amines by the addition of Grignard reagents to nitriles under microwave heating conditions

A series of carbinamines (α,α,α-trisubstituted amines) have been prepared in a simple and efficient one-pot procedure by the addition of Grignard reagents to a series of aliphatic, aromatic and heteroaromatic nitriles. The resulting magnesium imines are subsequently converted to the desired amine after treatment with Ti(Oi-Pr)4 and additional microwave heating. Key to this procedure is the use of microwave heating for both steps of the reaction protocol, which significantly improves both reaction yields and reduces reaction times. In general, the Grignard addition reaction is complete within 5-10 min at 100 °C followed by conversion with Ti(Oi-Pr)4 and additional microwave heating to give the target amines in good yields.

SYNTHESES OF 2-GUANIDINO-2-METHYLPROPYLAMINE DERIVATIVES.

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