6105-74-4

Usage

Uses

Used in Pharmaceutical Industry:
1,1-Dimethyl-2-piperidin-1-yl-ethylamine is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its reactivity and solubility properties to facilitate the creation of complex drug molecules.
Used in Organic Chemistry:
1,1-Dimethyl-2-piperidin-1-yl-ethylamine is utilized as a reagent in organic chemistry reactions, taking advantage of its amine functionality to participate in a range of chemical transformations, thereby contributing to the synthesis of diverse organic compounds.
Used in Research and Development:
1,1-Dimethyl-2-piperidin-1-yl-ethylamine is employed in research settings to explore its potential applications and to understand its chemical behavior, which can lead to the discovery of new uses and compounds.

InChI:InChI=1/C9H20N2/c1-9(2,10)8-11-6-4-3-5-7-11/h3-8,10H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 17697-46-0 1,1-Dimethyl-1-nitro-2-piperidinoethan 
• 3010-03-5 piperidin-1-yl-acetonitrile 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1265633-80-4 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(2-methyl-1-(piperidin-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide 
• 1174571-55-1 (E)-[2-(3-{4-[(1,1-Dimethyl-2-piperidin-1-yl-ethylamino)-(4-trifluoromethyl-phenylcarbamoyl)-methyl]-phenyl}-acryloylamino)-phenyl]-carbamic acid tert-butyl ester 
• 102129-05-5 N-(1,1-Dimethyl-2-piperidinoethyl)-N-(2-pyridyl)-propionamid 

Relevant academic research and scientific papers

NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS

The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

NOVEL C28-ANALOGUES WITH C3-MODIFICATIONS OF TRITERPENE DERIVATIVES AS HIV INHIBITORS

The present invention relates to compounds of novel C28-analogues with C3- modifications of triterpene derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, and Z are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.

Rapid Ti(Oi-Pr)4 facilitated synthesis of α,α,α-trisubstituted primary amines by the addition of Grignard reagents to nitriles under microwave heating conditions

A series of carbinamines (α,α,α-trisubstituted amines) have been prepared in a simple and efficient one-pot procedure by the addition of Grignard reagents to a series of aliphatic, aromatic and heteroaromatic nitriles. The resulting magnesium imines are subsequently converted to the desired amine after treatment with Ti(Oi-Pr)4 and additional microwave heating. Key to this procedure is the use of microwave heating for both steps of the reaction protocol, which significantly improves both reaction yields and reduces reaction times. In general, the Grignard addition reaction is complete within 5-10 min at 100 °C followed by conversion with Ti(Oi-Pr)4 and additional microwave heating to give the target amines in good yields.

Stereochemical researches about drugs. Part 11. Conformation of aminoalkyl acylamino-pyridines and their relation with morphine structure

The conformation of (R,S)-propiram and 8 analogues are investigated spectroscopically. Active analgesics are only found among the E-forms of the amides, in which the CH2 group of the propionyl substituent hangs over the pyridine ring - which itself stands vertical with respect to the planar amide group. The R-enantiomer of propiram is morphine-agonistic and corresponds to N-methylmorphinan in its spatial arrangement.