17697-46-0Relevant academic research and scientific papers
NOVEL C28-ANALOGUES WITH C3-MODIFICATIONS OF TRITERPENE DERIVATIVES AS HIV INHIBITORS
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Page/Page column 35, (2017/03/08)
The present invention relates to compounds of novel C28-analogues with C3- modifications of triterpene derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, and Z are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.
Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents
Francavilla, Charles,Low, Eddy,Nair, Satheesh,Kim, Bum,Shiau, Timothy P.,Debabov, Dmitri,Celeri, Chris,Alvarez, Nichole,Houchin, Ashley,Xu, Ping,Najafi, Ron,Jain, Rakesh
scheme or table, p. 2731 - 2734 (2010/03/03)
A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
