Chemical Property of Tiplasinin
Chemical Property:
- Vapor Pressure:1.14E-14mmHg at 25°C
- Melting Point:164-167℃
- Boiling Point:588°Cat760mmHg
- Flash Point:309.4°C
- PSA：68.53000
- Density:1.34g/cm3
- LogP:5.52250
- Storage Temp.:-20°C
- Solubility.:DMSO (Sparingly), Methanol (Slightly)
- XLogP3:5.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:439.10314248
- Heavy Atom Count:32
- Complexity:671
- Purity/Quality:
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99%, *data from raw suppliers
Tiplaxtinin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O
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Description
Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC50 = 2.7 μM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 μM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.
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Uses
Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.
