2-HYDROXYFORMANILIDE

Base Information

• Chemical Name: 2-HYDROXYFORMANILIDE
• CAS No.: 2843-27-8
• Molecular Formula: C7H7 N O2
• Molecular Weight: 137.138
• Hs Code.: 2928000090
• Mol file: 2843-27-8.mol

Synonyms:Formanilide,2'-hydroxy- (6CI,7CI,8CI); 2-Formamidophenol; 2-Hydroxyformanilide;2'-Hydroxyformanilide; N-(2-Hydroxyphenyl)formamide; N-Formyl-2-aminophenol;NSC 93900; o-Formamidophenol; o-Hydroxyformanilide

Chemical Property of 2-HYDROXYFORMANILIDE

Chemical Property:

• Vapor Pressure: 5.03E-05mmHg at 25°C
• Boiling Point: 338.4°Cat760mmHg
• Flash Point: 158.4°C
• PSA: 49.33000
• Density: 1.31g/cm³
• LogP: 1.66940

Purity/Quality:

99%min ^*data from raw suppliers

2''-Hydroxyformanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXYFORMANILIDE

There total 36 articles about 2-HYDROXYFORMANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-phenol (95-55-6) + formyl acetic anhydride (2258-42-6) → N-(2-hydroxyphenyl)formamide (2843-27-8)

Guidance literature:

In tetrahydrofuran; at -20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(00)87603-0

Reference yield: 96.0%

formic acid (64-18-6) + 2-amino-phenol (95-55-6) → N-(2-hydroxyphenyl)formamide (2843-27-8)

Guidance literature:

With sulfated tungstate; at 70 ℃; for 0.166667h; chemoselective reaction; Neat (no solvent);

DOI:10.1016/j.tetlet.2012.04.058

Reference yield: 96.0%

formic acid (64-18-6) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → N-(2-hydroxyphenyl)formamide (2843-27-8)

Guidance literature:

With silver and palladium nanoparticles immobilized over the surface of graphitic carbon nitride (g-C₃N₄); In water; for 2h; Irradiation;

DOI:10.1039/c5gc02799c

upstream raw materials:

benzoxazole

o-aminobenzaldehyde

formic acid

2-amino-phenol

Downstream raw materials:

N-(2-(1-ethoxyethoxy)phenyl)formamide

2-isocyano-1-(2-tetrahydro-2H-pyranyloxy)benzene

2-isocyano-1-(2-tetrahydrofuranyloxy)benzene

2-isocyano-1-(methoxymethoxy)benzene

Refernces

• 1、 Jadidi Nejad, Masoumeh,Heydari, Akbar. "Palladium supported on MRGO@CoAl-LDH catalyzed reductive carbonylation of nitroarenes and carbonylative Suzuki coupling reactions using formic acid as liquid CO and H2 source". . . Retrieved 2021/07/17.
• 2、 Nasrollahzadeh, Mahmoud,Bidgoli, Nayyereh Sadat Soheili,Rocha, Bruno G.M.,Pombeiro, Armando J.L.,Mahmudov, Kamran T.. "N-Formylation of amines using arylhydrazones of malononitrile and a Cu(II) complex under eco-friendly conditions at room temperature". . . Retrieved 2020/08/14.