3-(2-(4-Phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one

Base Information

Chemical Name:3-(2-(4-Phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one
CAS No.:134336-97-3
Molecular Formula:C18H20N4O2
Molecular Weight:324.382
Hs Code.:
DSSTox Substance ID:DTXSID00158651
Nikkaji Number:J528.056G
Wikidata:Q83026956
ChEMBL ID:CHEMBL356543
Mol file:134336-97-3.mol

Synonyms:3-(2-(4-phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one;3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxo-2,3-dihydro-oxazolo(4,5-b)pyridine chlorohydrate;3-(2-(4-phenylpiperazine-1-yl)ethyl)-2-oxo-2,3-dihydrooxazolo(b)pyridine;S 12813;S 12813-4;S-12813;S-12813-4;S12813

Suppliers and Price of 3-(2-(4-Phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-(2-(4-Phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one

Chemical Property:

Vapor Pressure:1.37E-10mmHg at 25°C
Boiling Point:511.8°C at 760 mmHg
Flash Point:263.3°C
Density:1.263g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:324.15862589
Heavy Atom Count:24
Complexity:433

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CCN2C3=C(C=CC=N3)OC2=O)C4=CC=CC=C4

Technology Process of 3-(2-(4-Phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one

There total 4 articles about 3-(2-(4-Phenyl-1-piperazinyl)ethyl)oxazolo(4,5-b)pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 92-54-6
4-phenyl-1-piperazine

: 134336-95-1
3-(2-bromoethyl)oxazolo<4,5-b>pyridin-2(3H)-one

: 134336-97-3
S 12813

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 60 ℃; for 12h;
DOI:10.1021/jm00056a010

Reference yield:

: 16867-03-1
2-amino-3-hydroxypyridine

: 134336-97-3
S 12813

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / tetrahydrofuran / 6 h / Heating

2: 1.) EtONa / 1.) EtOH, RT, 1 h, 2.) DMF, 110 deg C, 1 h

3: 97 percent / diisopropylethylamine / acetonitrile / 12 h / 60 °C

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00056a010

Reference yield:

: 60832-72-6
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

: 134336-97-3
S 12813

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) EtONa / 1.) EtOH, RT, 1 h, 2.) DMF, 110 deg C, 1 h

2: 97 percent / diisopropylethylamine / acetonitrile / 12 h / 60 °C

With sodium ethanolate; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/jm00056a010