N-Methyl bromoazepam

Base Information

• Chemical Name: N-Methyl bromoazepam
• CAS No.: 1812-33-5
• Molecular Formula: C₁₅H₁₂BrN₃O
• Molecular Weight: 330.184
• Hs Code.: 2933990090
• Mol file: 1812-33-5.mol

Synonyms:2H-1,4-Benzodiazepin-2-one,7-bromo-1,3-dihydro-1-methyl-5-(2-pyridyl)- (7CI,8CI); N1-Methylbromazepam

Chemical Property of N-Methyl bromoazepam

Chemical Property:

• Vapor Pressure: 1.66E-11mmHg at 25°C
• Boiling Point: 534.6°Cat760mmHg
• Flash Point: 277.1°C
• PSA: 45.56000
• Density: 1.51g/cm³
• LogP: 2.15850

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl bromoazepam

There total 1 articles about N-Methyl bromoazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 7-bromo-5-pyrido-1,4-benzodiazepin-2-one (1812-33-5)

Guidance literature:

Methyl-freie Verb., CH3I;

DOI:10.1002/jps.2600530303

Reference yield:

acetophenone (98-86-2) + 7-bromo-5-pyrido-1,4-benzodiazepin-2-one (1812-33-5) → syn-7-bromo-3-(1'-hydroxy-1'-phenylethyl)-1-methyl-5-(2'-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one + anti-7-bromo-3-(1'-hydroxy-1'-phenylethyl)-1-methyl-5-(2'-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:

7-bromo-5-pyrido-1,4-benzodiazepin-2-one; With (i-Pr)2Li; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

acetophenone; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

Reference yield:

benzaldehyde (100-52-7) + 7-bromo-5-pyrido-1,4-benzodiazepin-2-one (1812-33-5) → anti-(+)-7-bromo-3-(1'-hydroxy-1'-phenylmethyl)-1-methyl-5-(2'-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one + syn-(+)-7-bromo-3-(1'-hydroxy-1'-phenylmethyl)-1-methyl-5-(2'-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one + syn-(-)-7-bromo-3-(1'-hydroxy-1'-phenylmethyl)-1-methyl-5-(2'-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one + anti-(-)-7-bromo-3-(1'-hydroxy-1'-phenylmethyl)-1-methyl-5-(2'-pyridyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Guidance literature:

7-bromo-5-pyrido-1,4-benzodiazepin-2-one; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

chiral HPLC;

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