1,1,3-trimethyl-3-(3'-indolyl)-1,2,3,4-tetrahydrocyclopent(b)indole

Base Information

• Chemical Name: 1,1,3-trimethyl-3-(3'-indolyl)-1,2,3,4-tetrahydrocyclopent(b)indole
• CAS No.: 120551-57-7
• Molecular Formula: C₂₂H₂₂N₂
• Molecular Weight: 314.43
• Mol file: 120551-57-7.mol

Synonyms:1,1,3-trimethyl-3-(3'-indolyl)-1,2,3,4-tetrahydrocyclopent(b)indole

Chemical Property of 1,1,3-trimethyl-3-(3'-indolyl)-1,2,3,4-tetrahydrocyclopent(b)indole

Chemical Property:

• Boiling Point: 520.7°Cat760mmHg
• Flash Point: 230.5°C
• PSA: 31.58000
• Density: 1.189g/cm³
• LogP: 5.63650

Purity/Quality:

99%min ^*data from raw suppliers

1,1,3-TRIMETHYL-3-(3'-INDOLYL)-1,2,3,4-TETRAHYDROCYCLOPENT(B)INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1,3-trimethyl-3-(3'-indolyl)-1,2,3,4-tetrahydrocyclopent(b)indole

There total 2 articles about 1,1,3-trimethyl-3-(3'-indolyl)-1,2,3,4-tetrahydrocyclopent(b)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

indole (120-72-9) + 2,2-dimethoxy-propane (77-76-9) → 1,1,3-trimethyl-3-(3-indolyl)-1,2,3,4-tetrahydro-cyclopentindole (120551-57-7)

Guidance literature:

In ethanol; for 24h; Reflux;

DOI:10.1016/j.tet.2017.05.061

Reference yield: 12.0%

indole (120-72-9) + acetone (67-64-1) → 1,1,3-trimethyl-3-(3-indolyl)-1,2,3,4-tetrahydro-cyclopentindole (120551-57-7) + 1,1',4,4'-tetrahydro-1,1,1',1'-tetramethyl-3,3'(2H,2'H)-spirobiindole> (77250-80-7)

Guidance literature:

With trifluoroacetic acid; for 2.5h; Heating;

DOI:10.1016/S0040-4020(01)89501-6

Reference yield:

1,1,3-trimethyl-3-(3-indolyl)-1,2,3,4-tetrahydro-cyclopentindole (120551-57-7) + benzenesulfonyl chloride (98-09-9) → 1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole (117760-51-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) DMSO, 30 min, 2) 30 min;

DOI:10.1016/S0040-4020(01)89501-6

upstream raw materials:

indole

acetone

2,2-dimethoxy-propane

Downstream raw materials:

1,1,3-trimethyl-4-(phenylsulfonyl)-3--1,2,3,4-tetrahydrocyclopentindole

Refernces

• 1、 Bergman, Jan,Norrby, Per-Ola,Tilstam, Ulf,Venemalm, Lennart. "Structure Elucidation of Some Product Obtained by Acid-Catalyzed Condensation of Indole with Acetone". . p. 5549 - 5564. Retrieved 2007/10/02.