Formamide, N-methyl-N-(4-methylphenyl)-

Base Information

• Chemical Name: Formamide, N-methyl-N-(4-methylphenyl)-
• CAS No.: 2739-04-0
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID7062617
• Nikkaji Number: J28.434C
• Wikidata: Q81990147
• Mol file: 2739-04-0.mol

Synonyms:N,4'-Dimethylformanilide;2739-04-0;Formamide, N-methyl-N-(4-methylphenyl)-;n-methyl-n-(4-methylphenyl)formamide;N-Methyl-N-(p-tolyl)formamide;N,4-Dimethylformanilide;SCHEMBL2091673;DTXSID7062617;MQMOWSBDSHOJAV-UHFFFAOYSA-;CAA73904;MFCD09038515;AKOS013154140;D3369;T70701

Chemical Property of Formamide, N-methyl-N-(4-methylphenyl)-

Chemical Property:

• Vapor Pressure: 0.00384mmHg at 25°C
• Melting Point: 30oC
• Refractive Index: 1.55
• Boiling Point: 277 °C
• Flash Point: 127.4°C
• PSA: 20.31000
• Density: 1.057g/cm³
• LogP: 2.22350
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 128

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,4'-Dimethylformanilide >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N(C)C=O

Technology Process of Formamide, N-methyl-N-(4-methylphenyl)-

There total 51 articles about Formamide, N-methyl-N-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + N-methyl-p-toluidine (623-08-5) → N-methyl-N-(4-methylphenyl)formamide (2739-04-0)

Guidance literature:

With phenylsilane; In neat (no solvent); at 35 ℃; for 14h; under 7500.75 Torr; Autoclave;

DOI:10.1039/c8ta00823j

Reference yield: 90.0%

carbon monoxide (201230-82-2) + N-methyl-p-toluidine (623-08-5) → N-methyl-N-(4-methylphenyl)formamide (2739-04-0)

Guidance literature:

With phenylsilane; C₁₉H₃₇N₂⁽¹⁺⁾*Br^(1-); In neat (no solvent); at 20 ℃; for 12h; under 3750.38 Torr; Autoclave;

DOI:10.1016/j.cattod.2020.01.030

Reference yield: 85.0%

1-(4-methoxyphenyl)-2-(methyl(p-tolyl)amino)ethanone (1314108-46-7) → N-methyl-N-(4-methylphenyl)formamide (2739-04-0) + 4-methoxybenzoic acid (100-09-4)

Guidance literature:

With TEMPO; oxygen; In acetonitrile; at 50 ℃; for 13h; under 760.051 Torr;

DOI:10.1002/adsc.201100225

upstream raw materials:

Dimethyl-p-toluidine

N-(4-methylphenyl)formamide

methyl iodide

formic acid

Downstream raw materials:

N-methyl-N-(p-tolyl)-carbamoyl cyanide

Dimethyl-p-toluidine

2-[methyl(p-tolyl)amino]acetonitrile

(±)-2,8-dibromo-N-methyl-N-(p-tolyl)-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-13-amine

Refernces

• 1、 Wu, Shanxuan,Huang, Zijun,Jiang, Xiaolin,Yan, Fachao,Li, Yuehui,Du, Chen-Xia. "Recyclable Oxofluorovanadate-Catalyzed Formylation of Amines by Reductive Functionalization of CO2 with Hydrosilanes". . p. 1763 - 1766. Retrieved 2021/03/01.
• 2、 Ren, Qinggang,Chen, Yaju,Qiu, Yongjian,Tao, Leiming,Ji, Hongbing. "Ionization of Porous Hypercrosslinked Polymers for Catalyzing Room-Temperature CO2 Reduction via Formamides Synthesis". . p. 2919 - 2927. Retrieved 2021/02/01.