4(3H)-Quinazolinone, 3-(p-methoxyphenyl)-2-methyl-

Base Information

• Chemical Name: 4(3H)-Quinazolinone, 3-(p-methoxyphenyl)-2-methyl-
• CAS No.: 30507-16-5
• Molecular Formula: C16H14 N2 O2
• Molecular Weight: 266.299
• DSSTox Substance ID: DTXSID00184576
• Nikkaji Number: J73.096C
• Wikidata: Q83055481

Synonyms:BRN 0240106;4(3H)-Quinazolinone, 3-(p-methoxyphenyl)-2-methyl-;30507-16-5;3-(p-Methoxyphenyl)-2-methyl-4(3H)-quinazolinone;3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one;4(3H)-Quinazolinone, 3-(4-methoxyphenyl)-2-methyl-;ChemDiv3_003053;Oprea1_114737;Oprea1_663014;3-(4-Methoxy-phenyl)-2-methyl-3H-quinazolin-4-one;DTXSID00184576;HMS1481K17;STK721949;AKOS000622571;LS-141018;2-methyl-3-(p-methoxyphenyl)-4-quinazolone;SR-01000482935;SR-01000482935-1;BRD-K52638987-001-01-4;Z197514116

Chemical Property of 4(3H)-Quinazolinone, 3-(p-methoxyphenyl)-2-methyl-

Chemical Property:

• Vapor Pressure: 3.1E-08mmHg at 25°C
• Boiling Point: 448.5°C at 760 mmHg
• Flash Point: 225°C
• Density: 1.19g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 266.105527694
• Heavy Atom Count: 20
• Complexity: 399

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C(=O)N1C3=CC=C(C=C3)OC

Technology Process of 4(3H)-Quinazolinone, 3-(p-methoxyphenyl)-2-methyl-

There total 21 articles about 4(3H)-Quinazolinone, 3-(p-methoxyphenyl)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

isatoic anhydride (118-48-9) + 4-methoxy-aniline (104-94-9) + Triethyl orthoacetate (78-39-7) → 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one (30507-16-5)

Guidance literature:

In neat (no solvent); at 120 ℃; for 5h; Temperature; Green chemistry;

DOI:10.1039/c5ra03888j

Reference yield: 87.0%

4-methoxy-aniline (104-94-9) + o-acetylamino-benzoic acid (89-52-1) → 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one (30507-16-5)

Guidance literature:

With phosphorus trichloride; In acetonitrile; at 50 ℃; for 20h;

DOI:10.1021/jo049118e

Reference yield: 81.0%

2-amino-N-(4-methoxyphenyl)benzamide (20878-54-0) → 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one (30507-16-5)

Guidance literature:

With p-toluenesulfonic acid monohydrate; oxygen; at 110 ℃; Sealed tube; Green chemistry;

DOI:10.1039/d0gc01183e

upstream raw materials:

4-methoxy-aniline

o-acetylamino-benzoic acid

2-methyl-4-oxo-3,1-benzoxazine

anthranilic acid

Downstream raw materials:

1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-hydroxybenzene

2-Bromomethyl-3-(4-methoxy-phenyl)-3H-quinazolin-4-one

3-(4-Methoxy-phenyl)-2-[(2-p-tolyl-ethylamino)-methyl]-3H-quinazolin-4-one

2-{[2-(4-Chloro-phenyl)-ethylamino]-methyl}-3-(4-methoxy-phenyl)-3H-quinazolin-4-one

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