Thiazole, 2,5-di-2-thienyl-

Base Information

• Chemical Name: Thiazole, 2,5-di-2-thienyl-
• CAS No.: 54987-01-8
• Molecular Formula: C11H7NS3
• Molecular Weight: 249.375
• DSSTox Substance ID: DTXSID40203518
• Wikidata: Q83076917

Synonyms:2,5-dithiophen-2-yl-1,3-thiazole;Thiazole, 2,5-di-2-thienyl-;54987-01-8;2,5-di(2-thienyl)thiazole;Thiazole,2,5-di-2-thienyl-;SCHEMBL3072249;DTXSID40203518

Chemical Property of Thiazole, 2,5-di-2-thienyl-

Chemical Property:

• Vapor Pressure: 5.88E-07mmHg at 25°C
• Boiling Point: 422.5°C at 760 mmHg
• Flash Point: 204.5°C
• PSA: 97.61000
• Density: 1.372g/cm³
• LogP: 4.60010
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 248.97406275
• Heavy Atom Count: 15
• Complexity: 224

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C2=CN=C(S2)C3=CC=CS3

Technology Process of Thiazole, 2,5-di-2-thienyl-

There total 3 articles about Thiazole, 2,5-di-2-thienyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2,5-dibromo-1,3-thiazole (4175-78-4) + thiophene boronic acid (6165-68-0) → 2,5-di-(2-thienyl)thiazole (54987-01-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; for 4h; Heating;

DOI:10.3987/COM-89-S90

Reference yield:

2,5-dibromo-1,3-thiazole (4175-78-4) + thiophen-2-yl magnesium bromide (5713-61-1) → 2,5-di-(2-thienyl)thiazole (54987-01-8)

Guidance literature:

In diethyl ether; for 12h; Reflux;

DOI:10.1002/cjoc.201400654

Reference yield:

2-bromothiophene (1003-09-4) + 2-(thiophen-2-yl)thiazole (42140-95-4) → 2,5-di-(2-thienyl)thiazole (54987-01-8)

Guidance literature:

Multistep reaction; (i) nBuLi, Et₂O, (ii) Cu₂Cl₂;

upstream raw materials:

2-bromothiophene

2-(thiophen-2-yl)thiazole

2,5-dibromo-1,3-thiazole

thiophene boronic acid

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