3,4,6-trichloroguaiacol

Base Information

• Chemical Name: 3,4,6-trichloroguaiacol
• CAS No.: 60712-44-9
• Molecular Formula: C7H5 Cl3 O2
• Molecular Weight: 227.47
• Mol file: 60712-44-9.mol

Synonyms:3,4,6-Trichloroguaiacol

Chemical Property of 3,4,6-trichloroguaiacol

Chemical Property:

• Vapor Pressure: 0.00183mmHg at 25°C
• Boiling Point: 283.5°C at 760 mmHg
• Flash Point: 125.3°C
• PSA: 29.46000
• Density: 1.539g/cm³
• LogP: 3.36100

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,6-trichloroguaiacol

There total 8 articles about 3,4,6-trichloroguaiacol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3,4-Dichloro-2-methoxyphenol (77102-94-4) → 3,4,6-trichloroguaiacol (60712-44-9)

Guidance literature:

With sulfuryl dichloride; In acetic acid; at 50 ℃; for 1h;

DOI:10.1016/S0045-6535(00)00568-3

Reference yield:

3,4-dichloro-1,2-benzenediol (3978-67-4) → 3,4,6-trichloroguaiacol (60712-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / K₂CO₃ / acetone / 3 h / Heating

2: 71 percent / SO₂Cl₂ / acetic acid / 1 h / 50 °C

With sulfuryl dichloride; potassium carbonate; In acetic acid; acetone;

DOI:10.1016/S0045-6535(00)00568-3

Reference yield:

2-methoxy-6-chlorophenol (72403-03-3) → 3,4,6-trichloroguaiacol (60712-44-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / H₂SO₄ / 1 h / 50 °C

2: 64 percent / Cl₂ / acetic acid / 0.25 h / 20 °C

3: 63 percent / KOH / methanol; H₂O / 0.33 h / 50 °C

4: 45 percent / BBr₃ / 1,2-dichloro-ethane; CH₂Cl₂ / 1 h / Heating

5: 52 percent / K₂CO₃ / acetone / 3 h / Heating

6: 71 percent / SO₂Cl₂ / acetic acid / 1 h / 50 °C

With potassium hydroxide; sulfuryl dichloride; sulfuric acid; chlorine; boron tribromide; potassium carbonate; In methanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetone;

DOI:10.1016/S0045-6535(00)00568-3

upstream raw materials:

3,6-Dichloro-2-methoxyphenol

3,4-Dichloro-2-methoxyphenol

3,4-dichloro-1,2-benzenediol

2-methoxy-6-chlorophenol