3,4-dichloro-2-methoxyphenol

Base Information

• Chemical Name: 3,4-dichloro-2-methoxyphenol
• CAS No.: 77102-94-4
• Molecular Formula: C7H6 Cl2 O2
• Molecular Weight: 193.0273
• Mol file: 77102-94-4.mol

Synonyms:3,4-Dichloro-2-methoxyphenol;3,4-Dichloroguaiacol

Chemical Property of 3,4-dichloro-2-methoxyphenol

Chemical Property:

• Vapor Pressure: 0.00314mmHg at 25°C
• Boiling Point: 274.9°C at 760 mmHg
• Flash Point: 120°C
• PSA: 29.46000
• Density: 1.421g/cm³
• LogP: 2.70760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-dichloro-2-methoxyphenol

There total 7 articles about 3,4-dichloro-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3,4-dichloro-1,2-benzenediol (3978-67-4) + methyl iodide (74-88-4) → 3,4-Dichloro-2-methoxyphenol (77102-94-4)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Heating;

DOI:10.1016/S0045-6535(00)00568-3

Reference yield:

2-methoxy-6-chlorophenol (72403-03-3) → 3,4-Dichloro-2-methoxyphenol (77102-94-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / H₂SO₄ / 1 h / 50 °C

2: 64 percent / Cl₂ / acetic acid / 0.25 h / 20 °C

3: 63 percent / KOH / methanol; H₂O / 0.33 h / 50 °C

4: 45 percent / BBr₃ / 1,2-dichloro-ethane; CH₂Cl₂ / 1 h / Heating

5: 52 percent / K₂CO₃ / acetone / 3 h / Heating

With potassium hydroxide; sulfuric acid; chlorine; boron tribromide; potassium carbonate; In methanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetone;

DOI:10.1016/S0045-6535(00)00568-3

Reference yield:

2-methoxy-phenol (90-05-1) → 3,4-Dichloro-2-methoxyphenol (77102-94-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 38 percent / NaOCl (commercial bleach); NaOH / H₂O / 0.67 h / 25 °C

2: 100 percent / H₂SO₄ / 1 h / 50 °C

3: 64 percent / Cl₂ / acetic acid / 0.25 h / 20 °C

4: 63 percent / KOH / methanol; H₂O / 0.33 h / 50 °C

5: 45 percent / BBr₃ / 1,2-dichloro-ethane; CH₂Cl₂ / 1 h / Heating

6: 52 percent / K₂CO₃ / acetone / 3 h / Heating

With potassium hydroxide; sodium hydroxide; sodium hypochlorite; sulfuric acid; chlorine; boron tribromide; potassium carbonate; In methanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetone;

DOI:10.1016/S0045-6535(00)00568-3

upstream raw materials:

3,4-dichloro-1,2-benzenediol

dimethyl sulfate

methyl iodide

2-methoxy-6-chlorophenol

Downstream raw materials:

3,4,6-trichloroguaiacol