2-(methylamino)-N-(4-methylphenyl)acetamide

Base Information

• Chemical Name: 2-(methylamino)-N-(4-methylphenyl)acetamide
• CAS No.: 64642-17-7
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.234
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID70368407
• Wikidata: Q82154921
• Mol file: 64642-17-7.mol

Synonyms:2-(methylamino)-N-(4-methylphenyl)acetamide;64642-17-7;SCHEMBL171873;DTXSID70368407;MFCD03948088;STK504274;AKOS000117791;LS-02566;N~2~-methyl-N-(4-methylphenyl)glycinamide;CS-0246931;FT-0679293;EN300-34800;Z46191128;2-(METHYLAMINO)-N-(4-METHYLPHENYL)ACETAMIDEHYDROCHLORIDE

Chemical Property of 2-(methylamino)-N-(4-methylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 7.57E-05mmHg at 25°C
• Boiling Point: 342.4°C at 760 mmHg
• Flash Point: 146.9°C
• PSA: 41.13000
• LogP: 1.61680
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 178.110613074
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

98%min ^*data from raw suppliers

2-(Methylamino)-N-(4-methylphenyl)acetamidehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC(=O)CNC

Technology Process of 2-(methylamino)-N-(4-methylphenyl)acetamide

There total 2 articles about 2-(methylamino)-N-(4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(p-tolyl)-2-chloroacetamide (16634-82-5) + methylamine (74-89-5) → N-methyl-glycine 4-methyl-anilide (64642-17-7)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 24h;

DOI:10.1111/j.1747-0285.2011.01138.x

Reference yield:

p-toluidine (106-49-0,12221-03-3) → N-methyl-glycine 4-methyl-anilide (64642-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 0 °C

2: potassium carbonate / methanol / 24 h / 20 °C

With potassium carbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1111/j.1747-0285.2011.01138.x

Reference yield:

N-methyl-glycine 4-methyl-anilide (64642-17-7) + 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (86386-77-8) → C21H23F2N5O2 (1239174-79-8)

Guidance literature:

With triethylamine; In ethanol; for 9h; Reflux;

DOI:10.1111/j.1747-0285.2011.01138.x

upstream raw materials:

p-toluidine

N-(p-tolyl)-2-chloroacetamide

methylamine

Downstream raw materials:

5-acetyl-3-methyl-4-thio-hydantoic acid p-toluidide

5-(2,4-dichloro-benzoyl)-3-methyl-4-thio-hydantoic acid p-toluidide

5-benzoyl-3-methyl-4-thio-hydantoic acid p-toluidide

5-diphenoxyphosphoryl-3-methyl-4-thio-hydantoic acid p-toluidide

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