(6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID

Base Information

• Chemical Name: (6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID
• CAS No.: 59128-13-1
• Molecular Formula: C₉H₇ClN₂O₂
• Molecular Weight: 210.62
• Hs Code.: 2933990090
• Mol file: 59128-13-1.mol

Synonyms:NSC 296222

Chemical Property of (6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID

Chemical Property:

• Melting Point: 218-219 °C(Solv: ethanol (64-17-5))
• PKA: 1.79±0.10(Predicted)
• PSA: 54.60000
• Density: 1.5g/cm³
• LogP: 1.61480

Purity/Quality:

97% ^*data from raw suppliers

2-(6-Chloroimidazo[1,2-a]pyridin-2-yl)acetic acid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID

There total 3 articles about (6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-(6-chloroimidazo[1,2-a]pyridin-2-yl)acetate (59128-02-8) → 2-(6-chloroimidazo[1,2-a]pyridin-2-yl)acetic acid (59128-13-1)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

5-chloro-2-pyridylamine (1072-98-6) → 2-(6-chloroimidazo[1,2-a]pyridin-2-yl)acetic acid (59128-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 15 h / 90 °C

2: water; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C

With water; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

→ 2-(6-chloroimidazo[1,2-a]pyridin-2-yl)acetic acid (59128-13-1)

Guidance literature:

entspr. Ethylester (VII), HCl;

upstream raw materials:

5-chloro-2-pyridylamine

ethyl 2-(6-chloroimidazo[1,2-a]pyridin-2-yl)acetate

Downstream raw materials:

C₂₅H₂₆ClN₇O

C₂₇H₂₇ClN₆O

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