exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate

Base Information

Chemical Name:exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate
CAS No.:87168-44-3
Molecular Formula:C₁₅H₂₆N₂O₂*2ClH
Molecular Weight:339.306
Hs Code.:
DSSTox Substance ID:DTXSID501007377
Mol file:87168-44-3.mol

Synonyms:1-Pyrrolidinepropanoic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, endo-;exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate;1-Pyrrolidinepropanoic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, hydrate, exo- (2:4:1);87168-44-3;endo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride;87168-45-4;C15H26N2O2.2ClH;C15-H26-N2-O2.2Cl-H;DTXSID501007377;C15H26N2O2.2ClH.1/2H2O;LS-138127;LS-138128;C15-H26-N2-O2.2Cl-H.1/2H2-O;SR-01000395802;SR-01000395802-1;8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-(pyrrolidin-1-yl)propanoate--hydrogen chloride (1/2)

Suppliers and Price of exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-PYRROLIDINEPROPANOIC ACID, 8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTE R, DIHYDROCHLORIDE, HYDRATE, EXO-(2:4:1) 95.00%
5MG
$ 500.08

Total 0 raw suppliers

Chemical Property of exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate

Chemical Property:

Vapor Pressure:1.42E-05mmHg at 25°C
Boiling Point:366.9°C at 760 mmHg
Flash Point:175.7°C
PSA：32.78000
LogP:3.12050
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:338.1527835
Heavy Atom Count:21
Complexity:314

Purity/Quality:: 1-PYRROLIDINEPROPANOIC ACID, 8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTE R, DIHYDROCHLORIDE, HYDRATE, EXO-(2:4:1) 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2CCC1CC(C2)OC(=O)CCN3CCCC3.Cl.Cl

Technology Process of exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate

There total 4 articles about exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-1-pyrrolidinepropanoate dihydrochloride hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

: 123-75-1
pyrrolidine

: 3-Chloro-propionic acid (1R,3S,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride

: 87168-44-3,87168-45-4
3-Pyrrolidin-1-yl-propionic acid (1R,3S,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1007/BF00765640

Reference yield: 57.1%

: 123-75-1
pyrrolidine

: Tropinyl-β-chloropropionate hydrochloride

: 87168-44-3,87168-45-4
3-Pyrrolidin-1-yl-propionic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride

Guidance literature:: In ethanol; for 8h; Heating;
DOI:10.1007/BF00765640

Reference yield:

: 120-29-6
3-tropanol

: 87168-44-3,87168-45-4
3-Pyrrolidin-1-yl-propionic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / toluene / 4 h / Heating

2: 57.1 percent / ethanol / 8 h / Heating

In ethanol; toluene;
DOI:10.1007/BF00765640