N-(4-Methoxyphenyl)-N'-cyanoguanidine

Base Information

• Chemical Name: N-(4-Methoxyphenyl)-N'-cyanoguanidine
• CAS No.: 41988-52-7
• Molecular Formula: C9H10 N4 O
• Molecular Weight: 190.205
• NSC Number: 165771
• DSSTox Substance ID: DTXSID60962135
• Nikkaji Number: J599.036J
• Mol file: 41988-52-7.mol

Synonyms:41988-52-7;NSC165771;SCHEMBL11227303;DTXSID60962135;N-Cyano-N'-(4-methoxyphenyl)guanidine;NSC-165771

Chemical Property of N-(4-Methoxyphenyl)-N'-cyanoguanidine

Chemical Property:

• Vapor Pressure: 4.17E-05mmHg at 25°C
• Boiling Point: 351.2°C at 760 mmHg
• Flash Point: 166.2°C
• Density: 1.2g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 190.08546096
• Heavy Atom Count: 14
• Complexity: 247

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N=C(N)NC#N

Technology Process of N-(4-Methoxyphenyl)-N'-cyanoguanidine

There total 5 articles about N-(4-Methoxyphenyl)-N'-cyanoguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

sodium dicyanamide (1934-75-4) + 4-methoxy-aniline (104-94-9) → N-cyano-N'-(4-methoxyphenyl)guanidine (41988-52-7)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃; for 3h;

DOI:10.1016/j.ejmech.2016.09.051

Reference yield:

N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → N-cyano-N'-(4-methoxyphenyl)guanidine (41988-52-7)

Guidance literature:

With sodium hydroxide; Erwaermen des Reaktionsprodukts in 1-Aethoxy-aethanol-⁽²⁾ mit wss.Salzsaeure;

DOI:10.1039/jr9460000729

Reference yield:

p-anisidine hydrochloride (20265-97-8) → N-cyano-N'-(4-methoxyphenyl)guanidine (41988-52-7)

Guidance literature:

With 1,4-dioxane;

upstream raw materials:

3-cyano-2-methylisothiourea

4-methoxy-aniline

N-Cyanoguanidine

p-anisidine hydrochloride

Downstream raw materials:

N-(4-Methoxy-phenyl)-N'-(4-oxo-3,4-dihydro-quinazolin-2-yl)-guanidine

N-(4-Methoxy-phenyl)-N'-(4-oxo-3,4,5,6,7,8-hexahydro-benzo[4,5]thieno[2,3-d]pyrimidin-2-yl)-guanidine

Refernces