2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE

Base Information

• Chemical Name: 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE
• CAS No.: 38221-55-5
• Molecular Formula: C15H9ClF3NOS
• Molecular Weight: 343.757
• Hs Code.: 2934300000
• Mol file: 38221-55-5.mol

Synonyms:10H-Phenothiazine,10-(chloroacetyl)-2-(trifluoromethyl)- (9CI);NSC 71678;

Chemical Property of 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE

Chemical Property:

• Vapor Pressure: 3.13E-10mmHg at 25°C
• Refractive Index: 1.602
• Boiling Point: 502.6 °C at 760 mmHg
• Flash Point: 257.8 °C
• PSA: 45.61000
• Density: 1.476g/cm³
• LogP: 5.13850

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-1-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE

There total 2 articles about 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(trifluoromethyl)-10H-phenothiazine (92-30-8) + chloroacetyl chloride (79-04-9) → 2-chloro-1-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)ethanone (38221-55-5)

Guidance literature:

In toluene; at 0 - 80 ℃; for 12h;

DOI:10.1016/j.bmcl.2013.11.031

Reference yield:

→ 2-chloro-1-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)ethanone (38221-55-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 3h;

Reference yield: 92.0%

2-chloro-1-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)ethanone (38221-55-5) + 2-amino-5-(4-chlorophenyl)-1,3,4-thiadiazole (28004-62-8) → 2-(5-(4-chlorophenyl)-2-imino-1,3,4-thiadiazol-3(2H)-yl)-1-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)ethanone

Guidance literature:

In ethanol; at 80 - 85 ℃; for 17h;

DOI:10.1016/j.ejmech.2015.10.035

upstream raw materials:

2-(trifluoromethyl)-10H-phenothiazine

chloroacetyl chloride

Downstream raw materials:

2-trifluoromethyl-10-[(2,4,6-trioxo-5-phenyl-hexahydro-pyrimidin-5-yl)-acetyl]-10H-phenothiazine

2-{2-oxo-2-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]ethyl}-1H-isoindole-1,3(2H)-dione