2-(Trifluoromethyl)phenothiazine

Base Information

Chemical Name:2-(Trifluoromethyl)phenothiazine
CAS No.:92-30-8
Molecular Formula:C13H8F3NS
Molecular Weight:267.274
Hs Code.:29349990
European Community (EC) Number:202-145-7
NSC Number:50438
UNII:877S053KX3
DSSTox Substance ID:DTXSID3059050
Nikkaji Number:J4.352D
Wikidata:Q27164667
Pharos Ligand ID:YQQ9DM716Z4Q
ChEMBL ID:CHEMBL541018
Mol file:92-30-8.mol

Synonyms:trifluoromethylphenothiazine

Suppliers and Price of 2-(Trifluoromethyl)phenothiazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(Trifluoromethyl)phenothiazine
25g
$ 185.00

TRC
2-(Trifluoromethyl)phenothiazine
5g
$ 135.00

TCI Chemical
2-(Trifluoromethyl)phenothiazine >98.0%(GC)
25g
$ 81.00

SynQuest Laboratories
2-Trifluoromethyl-10H-phenothiazine 97%
25 g
$ 40.00

SynQuest Laboratories
2-Trifluoromethyl-10H-phenothiazine 97%
5 g
$ 10.00

Medical Isotopes, Inc.
2-(Trifluoromethyl)phenothiazine
100 g
$ 825.00

Matrix Scientific
2-Trifluoromethyl-10H-phenothiazine 97%
100g
$ 118.00

Matrix Scientific
2-Trifluoromethyl-10H-phenothiazine 97%
5g
$ 10.00

Matrix Scientific
2-Trifluoromethyl-10H-phenothiazine 97%
25g
$ 39.00

Frontier Specialty Chemicals
2-(Trifluoromethyl)phenothiazine 98%
5g
$ 22.00

Total 78 raw suppliers

Chemical Property of 2-(Trifluoromethyl)phenothiazine

Chemical Property:

Appearance/Colour:yellow to green powder
Vapor Pressure:1.49E-10mmHg at 25°C
Melting Point:188-190 °C(lit.)
Refractive Index:1.531
Boiling Point:361.1 °C at 760 mmHg
PKA:-2.60±0.20(Predicted)
Flash Point:172.2 °C
PSA：37.33000
Density:1.369 g/cm³
LogP:5.05160
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:267.03295492
Heavy Atom Count:18
Complexity:307

Purity/Quality:

99% ^*data from raw suppliers

2-(Trifluoromethyl)phenothiazine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi
Hazard Codes:Xn,Xi
Statements: 20/21/22-22
Safety Statements: 36-37/39-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)NC3=C(S2)C=CC(=C3)C(F)(F)F
Uses 2-(Trifluoromethyl)phenothiazine is used in the synthesis of antitubercolosis pharmaceuticals as well as antiproliferatives.

Technology Process of 2-(Trifluoromethyl)phenothiazine

There total 24 articles about 2-(Trifluoromethyl)phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 89507-40-4
10-<3-(4-methoxyethoxymethoxyethyl-1-piperazinyl)-3-oxopropyl>-2-trifluoromethyl-10H-phenothiazine

: 92-30-8
2-(trifluoromethyl)-10H-phenothiazine

: 89507-41-5
10-(3-hydroxy<3,3-2H2>propyl)-2-trifluoromethyl-10H-phenothiazine

Guidance literature:: With lithium aluminium deuteride; In diethyl ether; RT, 1 h, reflux, 30 min;
DOI:10.1002/jps.2600730123

Reference yield: 90.0%

: 583-55-1
1-Bromo-2-iodobenzene

: 19406-49-6
2-amino-4-trifluoromethylthiophenol

: 92-30-8
2-(trifluoromethyl)-10H-phenothiazine

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 48h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc30814b

Reference yield: 89.0%

: 6320-02-1
o-bromothiophenol

: 105202-02-6
2-iodo-4-(trifluoromethyl)benzenamine

: 92-30-8
2-(trifluoromethyl)-10H-phenothiazine

Guidance literature:: o-bromothiophenol; 2-iodo-4-(trifluoromethyl)benzenamine; With ferric citrate; In N,N-dimethyl-formamide; at 110 ℃; Green chemistry;

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; regioselective reaction; Green chemistry;
DOI:10.2174/1570178615666180806114523