4-BROMO-4'-METHYLBENZENESULFONANILIDE

Base Information

• Chemical Name: 4-BROMO-4'-METHYLBENZENESULFONANILIDE
• CAS No.: 7454-58-2
• Molecular Formula: C13H12BrNO2S
• Molecular Weight: 326.214
• Mol file: 7454-58-2.mol

Synonyms:4-Brom-benzolsulfonsaeure-p-toluidid;4-bromo-benzenesulfonic acid p-toluidide;N-p-tolyl-4-bromo-benzenesulfonamide;4-BROMO-4'-METHYLBENZENESULFONANILIDE;p-Brom-benzolsulfonsaeure-p-toluidid;

Chemical Property of 4-BROMO-4'-METHYLBENZENESULFONANILIDE

Chemical Property:

• Vapor Pressure: 1.19E-07mmHg at 25°C
• Boiling Point: 431.5°C at 760 mmHg
• Flash Point: 214.8°C
• PSA: 54.55000
• Density: 1.545g/cm³
• LogP: 4.71210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-4'-METHYLBENZENESULFONANILIDE

There total 7 articles about 4-BROMO-4'-METHYLBENZENESULFONANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-tolyl iodide (624-31-7) + 4-bromo-benzenesulfonic acid amide (701-34-8) → 4-bromo-n-(p-tolyl)benzenesulfonamide (7454-58-2)

Guidance literature:

With silver hexafluoroantimonate; chloro[di(1-adamantyl)-2-dimethylaminophenylphosphine]gold(I); In methanol; at 0 - 80 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03082

Reference yield: 84.0%

4-toluenesulfonyl azide (941-55-9) + 4-Bromophenylboronic acid (5467-74-3) → 4-bromo-n-(p-tolyl)benzenesulfonamide (7454-58-2)

Guidance literature:

With copper(l) chloride; In methanol; at 27 - 29 ℃; for 1h;

DOI:10.1039/c8ob01950a

Reference yield: 63.0%

1-methyl-4-nitrobenzene (99-99-0) + sodium 4-bromobenzenesulfinate (34176-08-4) → 4-bromo-n-(p-tolyl)benzenesulfonamide (7454-58-2)

Guidance literature:

With copper(l) chloride; In 1-methyl-pyrrolidin-2-one; water; at 120 ℃; for 40h; Inert atmosphere;

DOI:10.3390/molecules24071407

upstream raw materials:

p-toluidine

4-bromobenzenesulfonyl chloride

4-toluenesulfonyl azide

4-Bromophenylboronic acid

Downstream raw materials:

2-[(4-bromo-benzenesulfonyl)-p-tolyl-amino]-N,N-diethyl-acetamide

Refernces

• 1、 Liu, Saiwen,Chen, Ru,Zhang, Jin. "Copper-catalyzed redox coupling of nitroarenes with sodium sulfinates". . . Retrieved 2019/05/02.
• 2、 Azeez, Sadaf,Chaudhary, Priyanka,Sureshbabu, Popuri,Sabiah, Shahulhameed,Kandasamy, Jeyakumar. "Tert -Butyl nitrite mediated nitrogen transfer reactions: Synthesis of benzotriazoles and azides at room temperature". supporting information. p. 6902 - 6907. Retrieved 2018/10/02.