Isoniazid alpha-ketoglutaric acid

Base Information

Chemical Name:Isoniazid alpha-ketoglutaric acid
CAS No.:1152-31-4
Molecular Formula:C₁₁H₁₁N₃O₅
Molecular Weight:265.225
Hs Code.:
UNII:DVP7SNY72Q
ChEMBL ID:CHEMBL3544855
Mol file:1152-31-4.mol

Synonyms:1152-31-4;DVP7SNY72Q;CHEBI:80619;2-((4-Pyridinylcarbonyl)hydrazono)pentanedioic acid;Isoniazid alpha-ketoglutaric acid;Pentanedioic acid, 2-((4-pyridinylcarbonyl)hydrazono)-;Pentanedioic acid, 2-[(4-pyridinylcarbonyl)hydrazono]-;C11H11N3O5;C11-H11-N3-O5;Glutaric acid, 2-oxo-, 2-(isonicotinoylhydrazone);UNII-DVP7SNY72Q;Isoniazid alpha-ketoglutarate;CHEMBL3544855;ISONIAZID .ALPHA.-KETOGLUTARATE;.ALPHA.-KETOGLUTARIC ACID ISONICOTINOYLHYDRAZONE;(2E)-2-(pyridine-4-carbonylhydrazinylidene)pentanedioic acid;(2Z)-2-(pyridine-4-carbonylhydrazinylidene)pentanedioic acid;HYDRAZINE, 1-(1,3-DICARBOXYPROPYLIDENE)-2-ISONICOTINOYL-;4-PYRIDINECARBOXYLIC ACID, (1,3-DICARBOXYPROPYLIDENE)HYDRAZIDE

Suppliers and Price of Isoniazid alpha-ketoglutaric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Isoniazid alpha-ketoglutaric acid

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：128.95000
Density:1.45g/cm³
LogP:0.50770
XLogP3:0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:265.06987046
Heavy Atom Count:19
Complexity:388

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=CC=C1C(=O)NN=C(CCC(=O)O)C(=O)O
Isomeric SMILES:C1=CN=CC=C1C(=O)N/N=C(\CCC(=O)O)/C(=O)O

Technology Process of Isoniazid alpha-ketoglutaric acid

There total 2 articles about Isoniazid alpha-ketoglutaric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54-85-3,7640-37-1
isoniazid

: 328-50-7
α-ketoglutaric acid

: 1152-31-4
2-Oxo-glutarsaeure-isonicotinoylhydrazon

Guidance literature:: With methanol;

Reference yield:

: 1152-31-4
2-Oxo-glutarsaeure-isonicotinoylhydrazon

Guidance literature:: 2-Oxo-glutarsaeure, Isonicotinsaeurehydrazid (in W.), Δ;

Reference yield: 70.0%

: 67-56-1
methanol

: 1152-31-4
α-Oxopentanedioic acid isonicotinoyl hydrazone

: 1135-99-5
diphenyltin(IV) dichloride

: Sn(C₅H₄NNCONC(COO)(CH₂CH₂COOCH₃))(C₆H₅)2Cl(H₂O)*CH₃OH

Guidance literature:: With NaOEt; In methanol; oxoglutaric acid deriv. added to MeOH soln. of NaOEt; stirred for 0.5 h;then Ph2SnCl2 added; mixt. stirred for 10 h under reflux; cooled down t o room temp.; filtered, evapd. to dryness; recrystd. from CH2Cl2/MeOH; slowly evapd.; elem. anal.;
DOI:10.1002/zaac.201100170