1-Nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Base Information

Chemical Name:1-Nitro-4-(3-(trifluoromethyl)phenoxy)benzene
CAS No.:2303-26-6
Molecular Formula:C13H8F3NO3
Molecular Weight:283.207
Hs Code.:
NSC Number:52868
DSSTox Substance ID:DTXSID40287853
Wikidata:Q82024028
Mol file:2303-26-6.mol

Synonyms:2303-26-6;1-nitro-4-(3-(trifluoromethyl)phenoxy)benzene;1-(4-nitrophenoxy)-3-(trifluoromethyl)benzene;1-nitro-4-[3-(trifluoromethyl)phenoxy]benzene;Benzene, 1-(4-nitrophenoxy)-3-(trifluoromethyl)-;NSC52868;SCHEMBL2576415;DTXSID40287853;MFCD00246032;NSC 52868;NSC-52868;AKOS022169471;MS-7409

Suppliers and Price of 1-Nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 1-Nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Chemical Property:

Vapor Pressure:0.000478mmHg at 25°C
Boiling Point:324°Cat760mmHg
Flash Point:149.7°C
Density:1.378g/cm³
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:283.04562760
Heavy Atom Count:20
Complexity:335

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)OC2=CC=C(C=C2)[N+](=O)[O-])C(F)(F)F

Technology Process of 1-Nitro-4-(3-(trifluoromethyl)phenoxy)benzene

There total 5 articles about 1-Nitro-4-(3-(trifluoromethyl)phenoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 98-17-9
3-Trifluoromethylphenol

: 100-00-5
4-chlorobenzonitrile

: 2303-26-6
1-nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;
DOI:10.1016/j.bmc.2018.03.031

Reference yield: 49.0%

: 3-(4-nitrophenoxy)-5-(trifluoromethyl)aniline

: 2303-26-6
1-nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Guidance literature:: With sodium hydrogensulfite; acetic acid; sodium nitrite; In ethanol; water; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b01201

Reference yield:

: 349-57-5
3-nitro-5-(trifluoromethyl)phenol

: 2303-26-6
1-nitro-4-(3-(trifluoromethyl)phenoxy)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: sodium nitrite; acetic acid; sodium hydrogensulfite / ethanol; water / 8 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; sodium hydrogensulfite; acetic acid; sodium nitrite; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.9b01201