Phenol, 3-amino-2-bromo-

Base Information

• Chemical Name: Phenol, 3-amino-2-bromo-
• CAS No.: 100367-36-0
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.024
• Hs Code.: 2922299090
• Mol file: 100367-36-0.mol

Synonyms:2-BROMO-3-HYDROXYANILINE;Phenol,3-amino-2-bromo;2-bromo-3-aminophenol;

Chemical Property of Phenol, 3-amino-2-bromo-

Chemical Property:

• Boiling Point: 262.2±20.0 °C(Predicted)
• PKA: 8.48±0.10(Predicted)
• PSA: 46.25000
• Density: 1.768±0.06 g/cm3(Predicted)
• LogP: 2.31810
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-2-bromophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 3-amino-2-bromo-

There total 5 articles about Phenol, 3-amino-2-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Hexanoic acid 2-bromo-3-(2,2-dimethyl-propionylamino)-phenyl ester (168335-63-5) → 2-bromo-3-hydroxyaniline (100367-36-0)

Guidance literature:

With hydrogenchloride; In ethanol; Heating;

Reference yield: 58.0%

2-bromo-3-hydroxy-1-nitrobenzene (101935-40-4) → 2-bromo-3-hydroxyaniline (100367-36-0)

Guidance literature:

With iron; In ethanol; acetic acid; for 3.5h; Heating;

DOI:10.1021/jo00241a010

Reference yield:

N-(3-methoxyphenyl)pivalamide (56619-93-3) → 2-bromo-3-hydroxyaniline (100367-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi, 2.) bromine / 1.) THF, hexane, 0 deg C, 2.5 h, 2.) THF, hexane, -78 deg C, 1 h

2: 1.) AlCl₃ / 1.) CS₂, reflux, 3 h, 2.) 70 deg C, 2 d

3: 61 percent / ethanolic HCl / 12 h / 80 °C

With hydrogenchloride; n-butyllithium; aluminium trichloride; bromine;

DOI:10.1021/ja00130a003

upstream raw materials:

2-bromo-3-hydroxy-1-nitrobenzene

Hexanoic acid 2-bromo-3-(2,2-dimethyl-propionylamino)-phenyl ester

N-(3-methoxyphenyl)pivalamide

N-(2-bromo-3-methoxyphenyl)-2,2-dimethylpropionamide

Downstream raw materials:

(S)-4-[(Z)-3-(3-Amino-2-bromo-phenoxy)-propenyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

m-Hydroxyaniline

2-bromo-3-iodophenol

C₁₇H₂₆BrNOSi

Refernces

• 1、 -. "QUINAZOLINE COMPOUNDS". Paragraph 00408; 00409. . Retrieved 2015/06/11.
• 2、 Kozikowski, Alan P.,Ma, Dawei,Du, Linh,Lewin, Nancy E.,Blumberg, Peter M.. "Effect of alteration of the heterocyclic nucleus of ILV on its isoform selectivity for PKC. Palladium-catalyzed route to benzofuran analogues of ILV". . p. 6666 - 6672. Retrieved 2007/10/02.