4-chloro-N-[(diethylamino)carbonothioyl]benzamide

Base Information

• Chemical Name: 4-chloro-N-[(diethylamino)carbonothioyl]benzamide
• CAS No.: 101724-81-6
• Molecular Formula: C12H15ClN2OS
• Molecular Weight: 270.783
• Mol file: 101724-81-6.mol

Synonyms:N,N-diethyl-N'-(4-chloro-benzoyl)-thiourea;N,N-Diaethyl-N'-(4-chlor-benzoyl)-thioharnstoff;3-(4-Chloro-benzoyl)-1,1-diethyl-thiourea;

Chemical Property of 4-chloro-N-[(diethylamino)carbonothioyl]benzamide

Chemical Property:

• PSA: 64.43000
• LogP: 3.08740

Purity/Quality:

4-chloro-N-[(diethylamino)carbonothioyl]benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-N-[(diethylamino)carbonothioyl]benzamide

There total 4 articles about 4-chloro-N-[(diethylamino)carbonothioyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

diethylamine (109-89-7) + p-chlorobenzoyl isothiocyanate (16794-67-5) → N,N-diethyl-N′-(4-chlorobenzoyl)thiourea (101724-81-6)

Guidance literature:

for 2h;

DOI:10.1002/aoc.6348

Reference yield:

morpholine (110-91-8,99108-56-2) + p-chlorobenzoyl isothiocyanate (16794-67-5) → N,N-diethyl-N′-(4-chlorobenzoyl)thiourea (101724-81-6)

Guidance literature:

In acetone; at 20 ℃; for 2h;

DOI:10.1016/j.ica.2021.120590

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → N,N-diethyl-N′-(4-chlorobenzoyl)thiourea (101724-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 0.5 h / Reflux

2: acetone / 2 h

In acetone;

DOI:10.1080/00958972.2018.1427233

upstream raw materials:

4-chloro-benzoyl chloride

diethylamine

p-chlorobenzoyl isothiocyanate

morpholine

Downstream raw materials:

bis(N,N-diethyl-N′ -4-chlorobenzoylthioureato)copper(II)