1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-6-iodo-4-oxo-2-quinazolinyl)methyl)-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-6-iodo-4-oxo-2-quinazolinyl)methyl)-
CAS No.:134700-45-1
Molecular Formula:C28H23IN4O5
Molecular Weight:622.4105
Hs Code.:
DSSTox Substance ID:DTXSID70158885
Wikidata:Q83027178

Synonyms:BRN 4774588;1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-6-iodo-4-oxo-2-quinazolinyl)methyl)-;134700-45-1;C28H23IN4O5;DTXSID70158885;C28-H23-I-N4-O5;LS-84555

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-6-iodo-4-oxo-2-quinazolinyl)methyl)-

Chemical Property:

Vapor Pressure:2.75E-25mmHg at 25°C
Boiling Point:780.8°C at 760 mmHg
Flash Point:426°C
Density:1.71g/cm³
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:622.07132
Heavy Atom Count:38
Complexity:947

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1CC2=C(C=CC(=C2)N3C(=NC4=C(C3=O)C=C(C=C4)I)CN5C(=O)C6=CC=CC=C6C5=O)O

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-6-iodo-4-oxo-2-quinazolinyl)methyl)-

There total 4 articles about 1H-Isoindole-1,3(2H)-dione, 2-((3,4-dihydro-3-(4-hydroxy-3-(4-morpholinylmethyl)phenyl)-6-iodo-4-oxo-2-quinazolinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6780-38-7
N-phthaloylglycine chloride

: 134700-45-1
2-[3-(4-Hydroxy-3-morpholin-4-ylmethyl-phenyl)-6-iodo-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

3: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;

Reference yield:

: 134700-31-5
2-(6-Iodo-4-oxo-4H-benzo[d][1,3]oxazin-2-ylmethyl)-isoindole-1,3-dione

: 134700-45-1
2-[3-(4-Hydroxy-3-morpholin-4-ylmethyl-phenyl)-6-iodo-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / pyridine / Heating

2: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 134700-45-1
2-[3-(4-Hydroxy-3-morpholin-4-ylmethyl-phenyl)-6-iodo-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1) 0 to 5 deg C, 1h, 2) RT, overnight

2: 75 percent / pyridine / Heating

3: 1) EtOH, 1h, reflux, 2) 12h, reflux

With pyridine;