N-[(4-Methoxyphenyl)methylideneamino]-4-methyl-benzamide

Base Information

• Chemical Name: N-[(4-Methoxyphenyl)methylideneamino]-4-methyl-benzamide
• CAS No.: 51771-24-5
• Molecular Formula: C16H16N2O2
• European Community (EC) Number: 668-033-9
• DSSTox Substance ID: DTXSID10308468
• Mol file: 51771-24-5.mol

Synonyms:51771-24-5;N-[(4-METHOXYPHENYL)METHYLIDENEAMINO]-4-METHYL-BENZAMIDE;DTXSID10308468

Chemical Property of N-[(4-Methoxyphenyl)methylideneamino]-4-methyl-benzamide

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 268.121177757
• Heavy Atom Count: 20
• Complexity: 327

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)NN=CC2=CC=C(C=C2)OC

Technology Process of N-[(4-Methoxyphenyl)methylideneamino]-4-methyl-benzamide

There total 1 articles about N-[(4-Methoxyphenyl)methylideneamino]-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-benzaldehyde (123-11-5) + p-toluic hydrazide (3619-22-5) → C16H16N2O2 (51771-24-5)

Guidance literature:

In ethanol; for 3h; Reflux;

DOI:10.1016/j.ejmech.2008.10.034 DOI:10.1016/j.ejmech.2010.08.030

Reference yield: 70.0%

C16H16N2O2 (51771-24-5) → 2-(4-methoxyphenyl)-5-(p-tolyl)-1,3,4-oxadiazole (52596-94-8)

Guidance literature:

With N-chloro-succinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.75h;

DOI:10.1080/00397910903134592

Reference yield: 50.0%

C16H16N2O2 (51771-24-5) + acetic anhydride (108-24-7) → 2-(4-methoxyphenyl)-3-acetyl-5-(4-methylphenyl)-2,3-dihydro-1,3,4-oxadiazole (757217-22-4)

Guidance literature:

Reflux;

DOI:10.1021/jm2002876

upstream raw materials:

4-methoxy-benzaldehyde

p-toluic hydrazide

Downstream raw materials:

2-(4-methoxyphenyl)-5-(p-tolyl)-1,3,4-oxadiazole

C₂₂H₁₉N₃O₃

2-(4-methoxyphenyl)-3-acetyl-5-(4-methylphenyl)-2,3-dihydro-1,3,4-oxadiazole