pyroglutamyl-phenylalanyl-prolinamide

Base Information

• Chemical Name: pyroglutamyl-phenylalanyl-prolinamide
• CAS No.: 34783-35-2
• Molecular Formula: C19H24 N4 O4
• Molecular Weight: 372.42
• Mol file: 34783-35-2.mol

Synonyms:5: PN:US20020151502 PAGE: 9 claimed protein; Pyroglutamylphenylalanylprolinamide

Chemical Property of pyroglutamyl-phenylalanyl-prolinamide

Chemical Property:

• Vapor Pressure: 1.11E-27mmHg at 25°C
• Boiling Point: 829.6°Cat760mmHg
• Flash Point: 455.5°C
• PSA: 121.60000
• Density: 1.314g/cm³
• LogP: 0.82670

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of pyroglutamyl-phenylalanyl-prolinamide

There total 8 articles about pyroglutamyl-phenylalanyl-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + Boc-Gln-ONp (15387-45-8) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → L-pyroglutamyl-L-phenylalanine-L-proline amide (34783-35-2)

Guidance literature:

DOI:10.1023/A:1021270812985

Reference yield: 14.0%

methanol (67-56-1) + Z-pGlu-Phe-Pro-NH2 (69461-91-2) → L-pyroglutamyl-L-phenylalanine-L-proline amide (34783-35-2) + N-(benzyloxycarbonyl)-L-γ-methylglutamyl-L-phenylalanyl-L-prolinamide (88888-75-9)

Guidance literature:

for 168h; Ambient temperature;

DOI:10.1021/jm00372a006

Reference yield:

Z-pGlu-Phe-Pro-NH2 (69461-91-2) → L-pyroglutamyl-L-phenylalanine-L-proline amide (34783-35-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h; Yield given;

DOI:10.1021/jm00372a006

upstream raw materials:

methanol

Z-pGlu-Phe-Pro-NH₂

1-(tert-butoxycarbonyl)-L-proline

Boc-Gln-ONp

Refernces

• 1、 Szirtes, Tamas,Kisfaludy, Lajos,Palosi, Eva,Szporny, Laszlo. "Synthesis of Thyrotropin-Releasing Hormone Analogues. 1. Complete Dissociation of Central Nervous Effects from Thyrotropin-Releasing Activity". . p. 741 - 745. Retrieved 2007/10/02.