3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-, ethyl ester

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-, ethyl ester
• CAS No.: 103460-87-3
• Molecular Formula: C20H23F2N3O3
• Molecular Weight: 391.41200
• Hs Code.: 2933990090
• Mol file: 103460-87-3.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-, ethyl ester

Chemical Property:

• Boiling Point: 554.7±50.0 °C(Predicted)
• PKA: 8.57±0.40(Predicted)
• PSA: 63.57000
• Density: 1.336±0.06 g/cm3(Predicted)
• LogP: 2.98320
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1-cyclopropyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-, ethyl ester

There total 1 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester (94242-51-0) + (RS)-2-methylpiperazine (109-07-9) → 1-cyclopropyl-6,8-difluoro-7-(3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (103460-87-3)

Guidance literature:

DOI:10.1021/jm0510023

Reference yield: 35.0%

1-cyclopropyl-6,8-difluoro-7-(3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (103460-87-3) + 3-(4-Iodobutyl)-6-(3-ethyl-4-methylanilino)uracil (308833-37-6) → 1-cyclopropyl-7-(4-{4-[4-(3-ethyl-4-methyl-phenylamino)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyl}-3-methyl-piperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (479069-86-8)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm0510023

Reference yield:

1-cyclopropyl-6,8-difluoro-7-(3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (103460-87-3) → 1-cyclopropyl-7-(4-{4-[4-(3-ethyl-4-methyl-phenylamino)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyl}-3-methyl-piperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / NaHCO₃ / dimethylformamide / 20 °C

2: 89 percent / aq. LiOH / methanol / 20 °C

With lithium hydroxide; sodium hydrogencarbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0510023

upstream raw materials:

1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester

(RS)-2-methylpiperazine

Downstream raw materials:

1-cyclopropyl-7-(4-{4-[4-(3-ethyl-4-methyl-phenylamino)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyl}-3-methyl-piperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Refernces